Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung
Differential diagnosis disseminated diseases provides sarcoidosis and tuberculosis. Frequency of mistakes consists over 40% [Visel AA, 2013]. That’s why including of new diagnosis methods is weary important. Оbjective: to indicat diagnosis value of immunologic methods in differential diagnosis with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2015-07-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/404 |
| _version_ | 1797695252611465216 |
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| author | M. А. Belokurov A. А. Starshinova V. Yu. Zhuravlev L. D. Kiruchina М. V. Pavlova I. V. Chernokhaeva L. I. Archakova A. R. Kozak V. A. Tsinzerling P. K. Yablonskii |
| author_facet | M. А. Belokurov A. А. Starshinova V. Yu. Zhuravlev L. D. Kiruchina М. V. Pavlova I. V. Chernokhaeva L. I. Archakova A. R. Kozak V. A. Tsinzerling P. K. Yablonskii |
| author_sort | M. А. Belokurov |
| collection | DOAJ |
| description | Differential diagnosis disseminated diseases provides sarcoidosis and tuberculosis. Frequency of mistakes consists over 40% [Visel AA, 2013]. That’s why including of new diagnosis methods is weary important. Оbjective: to indicat diagnosis value of immunologic methods in differential diagnosis with sarcoidosis and tuberculosis. In the department of phthisiopulmonology were examined 66 patients with lung over 2013 to 2014. Complex of examination included: examination of the respiratory excretion material (sputum) for detection of MBT using laboratory methods, X-ray examination (computed tomography), histological examination after transbronchial biopsy of lung tissue. All of diagnosis were proved by histological and bacteriological methods. After complex of examination patients were divided in two groups: I group (n=32) – pulmonary TB; II group (n=17) – sarcoidosis II study. All of patients were examined with immunologic tests (tuberculin skin test (TST), Diaskintest® (DST) QuantiFERON ®-TB Gold (QFT) and T.-SPOT.TB test (T-SPOT). In the I group this tests was significant different positive results with QFT (78,1%), T-SPOT (71,9%), DST (81,3%) in comparison with negative results of this tests (p˂0,001). Diagnostic value was: TST (DSe – 84,4%, DSp – 40,0%, Dv – 70,2%, PVPR – 75,0%, PVNR – 54,5%); QFT (DSe – 74,2%, DSp – 88,2%, Dv – 79,2%, PVPR – 92,0%, PVNR – 65,2%); TB.SPOT (DSe – 80,6%, DSp – 87,5%, Dv – 83,0%, PVPR – 92,6%, PVNR – 70,0%); DST (DSe – 81,3%, DSp – 94,1%, Dv – 85,7%, PVPR – 96,3%, PVNR – 72,7%); Сonclusion: diagnostic value of immunologic tests QFT, TB.SPOT and DST was more significantly higher in comparison with TST. The use of immunological tests can help in differential diagnosis of tuberculosis and sarcoidosis. |
| first_indexed | 2024-03-12T03:08:32Z |
| format | Article |
| id | doaj.art-df17eb8580fb4ceda48358021c9d5c99 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T03:08:32Z |
| publishDate | 2015-07-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-df17eb8580fb4ceda48358021c9d5c992023-09-03T14:30:00ZrusJournal InfectologyЖурнал инфектологии2072-67322015-07-01729810410.22625/2072-6732-2015-7-2-98-104411Immunological methods in diagnosis of sarcoidosis end tuberculosis of lungM. А. Belokurov0A. А. Starshinova1V. Yu. Zhuravlev2L. D. Kiruchina3М. V. Pavlova4I. V. Chernokhaeva5L. I. Archakova6A. R. Kozak7V. A. Tsinzerling8P. K. Yablonskii9Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияСанкт-Петербургский научно-исследовательский институт фтизиопульмонологии, Санкт-Петербург, РоссияDifferential diagnosis disseminated diseases provides sarcoidosis and tuberculosis. Frequency of mistakes consists over 40% [Visel AA, 2013]. That’s why including of new diagnosis methods is weary important. Оbjective: to indicat diagnosis value of immunologic methods in differential diagnosis with sarcoidosis and tuberculosis. In the department of phthisiopulmonology were examined 66 patients with lung over 2013 to 2014. Complex of examination included: examination of the respiratory excretion material (sputum) for detection of MBT using laboratory methods, X-ray examination (computed tomography), histological examination after transbronchial biopsy of lung tissue. All of diagnosis were proved by histological and bacteriological methods. After complex of examination patients were divided in two groups: I group (n=32) – pulmonary TB; II group (n=17) – sarcoidosis II study. All of patients were examined with immunologic tests (tuberculin skin test (TST), Diaskintest® (DST) QuantiFERON ®-TB Gold (QFT) and T.-SPOT.TB test (T-SPOT). In the I group this tests was significant different positive results with QFT (78,1%), T-SPOT (71,9%), DST (81,3%) in comparison with negative results of this tests (p˂0,001). Diagnostic value was: TST (DSe – 84,4%, DSp – 40,0%, Dv – 70,2%, PVPR – 75,0%, PVNR – 54,5%); QFT (DSe – 74,2%, DSp – 88,2%, Dv – 79,2%, PVPR – 92,0%, PVNR – 65,2%); TB.SPOT (DSe – 80,6%, DSp – 87,5%, Dv – 83,0%, PVPR – 92,6%, PVNR – 70,0%); DST (DSe – 81,3%, DSp – 94,1%, Dv – 85,7%, PVPR – 96,3%, PVNR – 72,7%); Сonclusion: diagnostic value of immunologic tests QFT, TB.SPOT and DST was more significantly higher in comparison with TST. The use of immunological tests can help in differential diagnosis of tuberculosis and sarcoidosis.https://journal.niidi.ru/jofin/article/view/404саркоидоз, туберкулез, дифференциальная диагностика, иммунологические методы, t-spot.tb.тест, диаскинтест, quantiferon-tb gold |
| spellingShingle | M. А. Belokurov A. А. Starshinova V. Yu. Zhuravlev L. D. Kiruchina М. V. Pavlova I. V. Chernokhaeva L. I. Archakova A. R. Kozak V. A. Tsinzerling P. K. Yablonskii Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung Журнал инфектологии саркоидоз, туберкулез, дифференциальная диагностика, иммунологические методы, t-spot.tb.тест, диаскинтест, quantiferon-tb gold |
| title | Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| title_full | Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| title_fullStr | Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| title_full_unstemmed | Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| title_short | Immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| title_sort | immunological methods in diagnosis of sarcoidosis end tuberculosis of lung |
| topic | саркоидоз, туберкулез, дифференциальная диагностика, иммунологические методы, t-spot.tb.тест, диаскинтест, quantiferon-tb gold |
| url | https://journal.niidi.ru/jofin/article/view/404 |
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