PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue

PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue

Abstract Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas and medulloblastomas. The PTCH1 gene, responsible for NBCCS, suppresses the hedgehog signaling pathway, which is recognized as one of the impor...

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Bibliographic Details
Main Authors: Kazuaki Nagao, Chise Kato, Yu Ikemoto, Toshino Motojima, Katsunori Fujii, Akihiro Umezawa, Toshiyuki Miyashita
Format: Article
Language:English
Published: Springer 2022-05-01
Series:Discover Oncology
Subjects:
Nevoid basal cell carcinoma syndrome
PTCH1
Medulloblastoma
iPSCs
Online Access:https://doi.org/10.1007/s12672-022-00498-x

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