Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides)
Biodegradable poly(carbonate anhydrides) based on poly(trimethylene carbonate) were synthesized by ring-opening polymerization. The hydroxyl-terminated oligomers were acid-functionalized with succinic anhydride and subsequently methacrylated to obtain photo-crosslinkable three-armed macromers with a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Budapest University of Technology
2020-04-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0010367&mi=cd |
| _version_ | 1818369192166948864 |
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| author | B. van Bochove J. V. Seppala |
| author_facet | B. van Bochove J. V. Seppala |
| author_sort | B. van Bochove |
| collection | DOAJ |
| description | Biodegradable poly(carbonate anhydrides) based on poly(trimethylene carbonate) were synthesized by ring-opening polymerization. The hydroxyl-terminated oligomers were acid-functionalized with succinic anhydride and subsequently methacrylated to obtain photo-crosslinkable three-armed macromers with anhydride bonds. The degree of acid-functionalization was over 96%, and the degree of methacrylation was over 80%. The macromers were photo-crosslinked into networks at room temperature in a nitrogen atmosphere. In vitro degradation experiments in phosphate-buffered solution (pH 7.4) at 37 °C showed that the networks degraded rapidly with complete mass loss within 72 h. For networks prepared from the higher molecular weight, the presence of an alkenyl chain in the anhydride bond resulted in lower water uptake and consequently in a decrease in the degradation rate. The degradation mechanism of these networks showed characteristics of surface erosion. |
| first_indexed | 2024-12-13T23:19:56Z |
| format | Article |
| id | doaj.art-df18d08ad8ba47bdaa3543def0b09d16 |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-12-13T23:19:56Z |
| publishDate | 2020-04-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-df18d08ad8ba47bdaa3543def0b09d162022-12-21T23:27:48ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2020-04-0114435836710.3144/expresspolymlett.2020.30Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides)B. van BochoveJ. V. SeppalaBiodegradable poly(carbonate anhydrides) based on poly(trimethylene carbonate) were synthesized by ring-opening polymerization. The hydroxyl-terminated oligomers were acid-functionalized with succinic anhydride and subsequently methacrylated to obtain photo-crosslinkable three-armed macromers with anhydride bonds. The degree of acid-functionalization was over 96%, and the degree of methacrylation was over 80%. The macromers were photo-crosslinked into networks at room temperature in a nitrogen atmosphere. In vitro degradation experiments in phosphate-buffered solution (pH 7.4) at 37 °C showed that the networks degraded rapidly with complete mass loss within 72 h. For networks prepared from the higher molecular weight, the presence of an alkenyl chain in the anhydride bond resulted in lower water uptake and consequently in a decrease in the degradation rate. The degradation mechanism of these networks showed characteristics of surface erosion.http://www.expresspolymlett.com/letolt.php?file=EPL-0010367&mi=cdbiodegradable polymerspoly(trimethylene carbonate)poly(anhydrides)polymer degradationpolymer networks |
| spellingShingle | B. van Bochove J. V. Seppala Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) eXPRESS Polymer Letters biodegradable polymers poly(trimethylene carbonate) poly(anhydrides) polymer degradation polymer networks |
| title | Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) |
| title_full | Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) |
| title_fullStr | Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) |
| title_full_unstemmed | Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) |
| title_short | Synthesis and characterization of photo-crosslinked poly(carbonate anhydrides) |
| title_sort | synthesis and characterization of photo crosslinked poly carbonate anhydrides |
| topic | biodegradable polymers poly(trimethylene carbonate) poly(anhydrides) polymer degradation polymer networks |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0010367&mi=cd |
| work_keys_str_mv | AT bvanbochove synthesisandcharacterizationofphotocrosslinkedpolycarbonateanhydrides AT jvseppala synthesisandcharacterizationofphotocrosslinkedpolycarbonateanhydrides |