Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review
Human immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV types and the activation of low risk types. The Cente...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000100001 |
| _version_ | 1827844813108543488 |
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| author | Alcina Frederica Nicol Ana Teresa Gomes Fernandes Maria da Gloria Bonecini-Almeida |
| author_facet | Alcina Frederica Nicol Ana Teresa Gomes Fernandes Maria da Gloria Bonecini-Almeida |
| author_sort | Alcina Frederica Nicol |
| collection | DOAJ |
| description | Human immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV types and the activation of low risk types. The Center for Disease Control and Prevention declared invasive cervical cancer an acquired immunodeficience virus (AIDS) defining illness in HIV positive women. Furthermore, cervical cancer happens to be the second most common female cancer worldwide. The host's local immune response plays a critical factor in controlling these conditions, as well as in changes in the number of professional antigen-presenting cells, cytokine, and MHC molecules expression. Also, the production of cytokines may determine which arm of the immune response will be stimulated and may influence the magnitude of immune protection. Although there are many studies describing the inflammatory response in HPV infection, few data are available to demonstrate the influence of the HIV infection and several questions regarding the cervical immune response are still unknown. In this review we present a brief account of the current understanding of HIV/HPV co-infection, emphasizing cervical immune response. |
| first_indexed | 2024-03-12T08:47:16Z |
| format | Article |
| id | doaj.art-df18f3945bde42c9947be3f3851c141f |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:47:16Z |
| publishDate | 2005-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-df18f3945bde42c9947be3f3851c141f2023-09-02T16:25:41ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-02-01100111210.1590/S0074-02762005000100001Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - reviewAlcina Frederica NicolAna Teresa Gomes FernandesMaria da Gloria Bonecini-AlmeidaHuman immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV types and the activation of low risk types. The Center for Disease Control and Prevention declared invasive cervical cancer an acquired immunodeficience virus (AIDS) defining illness in HIV positive women. Furthermore, cervical cancer happens to be the second most common female cancer worldwide. The host's local immune response plays a critical factor in controlling these conditions, as well as in changes in the number of professional antigen-presenting cells, cytokine, and MHC molecules expression. Also, the production of cytokines may determine which arm of the immune response will be stimulated and may influence the magnitude of immune protection. Although there are many studies describing the inflammatory response in HPV infection, few data are available to demonstrate the influence of the HIV infection and several questions regarding the cervical immune response are still unknown. In this review we present a brief account of the current understanding of HIV/HPV co-infection, emphasizing cervical immune response.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000100001human papillomavirushuman immunodeficiency virus-1cervical intraepithelial neoplasiacervical immunity responsewomen |
| spellingShingle | Alcina Frederica Nicol Ana Teresa Gomes Fernandes Maria da Gloria Bonecini-Almeida Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review Memorias do Instituto Oswaldo Cruz human papillomavirus human immunodeficiency virus-1 cervical intraepithelial neoplasia cervical immunity response women |
| title | Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review |
| title_full | Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review |
| title_fullStr | Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review |
| title_full_unstemmed | Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review |
| title_short | Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review |
| title_sort | immune response in cervical dysplasia induced by human papillomavirus the influence of human immunodeficiency virus 1 co infection review |
| topic | human papillomavirus human immunodeficiency virus-1 cervical intraepithelial neoplasia cervical immunity response women |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000100001 |
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