Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes
Substance use disorder (SUD) is comorbid with devastating health issues, social withdrawal, and isolation. Successful clinical treatments for SUD have used social interventions. Neurons can encode drug cues, and drug cues can trigger relapse. It is important to study how the activity in circuits and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.762441/full |
| _version_ | 1818984038006784000 |
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| author | Nicholas J. Beacher Kayden A. Washington Craig T. Werner Craig T. Werner Yan Zhang Giovanni Barbera Yun Li Da-Ting Lin |
| author_facet | Nicholas J. Beacher Kayden A. Washington Craig T. Werner Craig T. Werner Yan Zhang Giovanni Barbera Yun Li Da-Ting Lin |
| author_sort | Nicholas J. Beacher |
| collection | DOAJ |
| description | Substance use disorder (SUD) is comorbid with devastating health issues, social withdrawal, and isolation. Successful clinical treatments for SUD have used social interventions. Neurons can encode drug cues, and drug cues can trigger relapse. It is important to study how the activity in circuits and embedded cell types that encode drug cues develop in SUD. Exploring shared neurobiology between social interaction (SI) and SUD may explain why humans with access to social treatments still experience relapse. However, circuitry remains poorly characterized due to technical challenges in studying the complicated nature of SI and SUD. To understand the neural correlates of SI and SUD, it is important to: (1) identify cell types and circuits associated with SI and SUD, (2) record and manipulate neural activity encoding drug and social rewards over time, (3) monitor unrestrained animal behavior that allows reliable drug self-administration (SA) and SI. Miniaturized fluorescence microscopes (miniscopes) are ideally suited to meet these requirements. They can be used with gradient index (GRIN) lenses to image from deep brain structures implicated in SUD. Miniscopes can be combined with genetically encoded reporters to extract cell-type specific information. In this mini-review, we explore how miniscopes can be leveraged to uncover neural components of SI and SUD and advance potential therapeutic interventions. |
| first_indexed | 2024-12-20T18:12:38Z |
| format | Article |
| id | doaj.art-df196171822a43c9a034412441d15cd8 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-20T18:12:38Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-df196171822a43c9a034412441d15cd82022-12-21T19:30:26ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102021-10-011510.3389/fncir.2021.762441762441Circuit Investigation of Social Interaction and Substance Use Disorder Using MiniscopesNicholas J. Beacher0Kayden A. Washington1Craig T. Werner2Craig T. Werner3Yan Zhang4Giovanni Barbera5Yun Li6Da-Ting Lin7Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesDepartment of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, United StatesIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesDepartment of Zoology and Physiology, University of Wyoming, Laramie, WY, United StatesIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United StatesSubstance use disorder (SUD) is comorbid with devastating health issues, social withdrawal, and isolation. Successful clinical treatments for SUD have used social interventions. Neurons can encode drug cues, and drug cues can trigger relapse. It is important to study how the activity in circuits and embedded cell types that encode drug cues develop in SUD. Exploring shared neurobiology between social interaction (SI) and SUD may explain why humans with access to social treatments still experience relapse. However, circuitry remains poorly characterized due to technical challenges in studying the complicated nature of SI and SUD. To understand the neural correlates of SI and SUD, it is important to: (1) identify cell types and circuits associated with SI and SUD, (2) record and manipulate neural activity encoding drug and social rewards over time, (3) monitor unrestrained animal behavior that allows reliable drug self-administration (SA) and SI. Miniaturized fluorescence microscopes (miniscopes) are ideally suited to meet these requirements. They can be used with gradient index (GRIN) lenses to image from deep brain structures implicated in SUD. Miniscopes can be combined with genetically encoded reporters to extract cell-type specific information. In this mini-review, we explore how miniscopes can be leveraged to uncover neural components of SI and SUD and advance potential therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fncir.2021.762441/fullminiature fluorescence microscopyminiscopein vivo calcium imaginglongitudinal imagingsubstance use disordersocial interaction |
| spellingShingle | Nicholas J. Beacher Kayden A. Washington Craig T. Werner Craig T. Werner Yan Zhang Giovanni Barbera Yun Li Da-Ting Lin Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes Frontiers in Neural Circuits miniature fluorescence microscopy miniscope in vivo calcium imaging longitudinal imaging substance use disorder social interaction |
| title | Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes |
| title_full | Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes |
| title_fullStr | Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes |
| title_full_unstemmed | Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes |
| title_short | Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes |
| title_sort | circuit investigation of social interaction and substance use disorder using miniscopes |
| topic | miniature fluorescence microscopy miniscope in vivo calcium imaging longitudinal imaging substance use disorder social interaction |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.762441/full |
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