Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice
Type 2 diabetes mellitus (T2DM) is one of the biggest public health issues worldwide and closely related to development of other chronic diseases such as cardiovascular diseases, cancer and neurodegenerative diseases. Considerable percentage of T2DM patients undergo have suffered from binge eating d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/full |
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| author | Hyeyoon Eo Seong Hye Kim In Gyoung Ju Eugene Huh Sinyeon Kim Jin Gyu Choi Se Woong Kim Miwon Son Myung Sook Oh Myung Sook Oh |
| author_facet | Hyeyoon Eo Seong Hye Kim In Gyoung Ju Eugene Huh Sinyeon Kim Jin Gyu Choi Se Woong Kim Miwon Son Myung Sook Oh Myung Sook Oh |
| author_sort | Hyeyoon Eo |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is one of the biggest public health issues worldwide and closely related to development of other chronic diseases such as cardiovascular diseases, cancer and neurodegenerative diseases. Considerable percentage of T2DM patients undergo have suffered from binge eating disorder which exacerbates insulin resistance and metabolic challenges. Longan (Dimocarpus longan L.) and its constituents are reported for their various health benefits. However, it is still unknown whether longan fruit supplementation can ameliorate glucose homeostasis and binge eating disorder found in T2DM. The current study aimed to investigate whether longan fruit extract (LE) supplementation can improve diabetic hyperglycemia through modulation of feeding center located in hypothalamus of db/db T2DM mice. As a result, LE supplementation ameliorated fasting blood glucose levels and reduced excessive epididymal fat accumulation. In addition, LE administration improved glucose tolerance and insulin sensitivity in db/db mice. Especially, LE supplemented mice showed less food consumption which was in line with increase of pro-opiomelanocortin (POMC) neuronal activities and decrease of agouti-related peptide (AgRP) neuronal activities. Furthermore, LE supplementation reduced hypothalamic endoplasmic reticulum (ER) stress which was stimulated in db/db mice. As ER stress is a crucial factor involving in appetite control and glucose homeostasis, the effect of LE supplementation on circulating glucose levels and feeding behavior might be mediated by suppression of hypothalamic ER stress. Collectively, these findings suggest that LE could be a potential nutraceutical for improvement of T2DM as well as patients with satiety issues. |
| first_indexed | 2024-03-13T04:04:43Z |
| format | Article |
| id | doaj.art-df19e62eb4cb4d3f8b2441b52e245bc0 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T04:04:43Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-df19e62eb4cb4d3f8b2441b52e245bc02023-06-21T08:27:44ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.11436131143613Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db miceHyeyoon Eo0Seong Hye Kim1In Gyoung Ju2Eugene Huh3Sinyeon Kim4Jin Gyu Choi5Se Woong Kim6Miwon Son7Myung Sook Oh8Myung Sook Oh9Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of KoreaDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of KoreaDepartment of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of KoreaDepartment of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of KoreaMThera Pharma Co., Seoul, Republic of KoreaMThera Pharma Co., Seoul, Republic of KoreaMThera Pharma Co., Seoul, Republic of KoreaMThera Pharma Co., Seoul, Republic of KoreaDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of KoreaDepartment of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, Republic of KoreaType 2 diabetes mellitus (T2DM) is one of the biggest public health issues worldwide and closely related to development of other chronic diseases such as cardiovascular diseases, cancer and neurodegenerative diseases. Considerable percentage of T2DM patients undergo have suffered from binge eating disorder which exacerbates insulin resistance and metabolic challenges. Longan (Dimocarpus longan L.) and its constituents are reported for their various health benefits. However, it is still unknown whether longan fruit supplementation can ameliorate glucose homeostasis and binge eating disorder found in T2DM. The current study aimed to investigate whether longan fruit extract (LE) supplementation can improve diabetic hyperglycemia through modulation of feeding center located in hypothalamus of db/db T2DM mice. As a result, LE supplementation ameliorated fasting blood glucose levels and reduced excessive epididymal fat accumulation. In addition, LE administration improved glucose tolerance and insulin sensitivity in db/db mice. Especially, LE supplemented mice showed less food consumption which was in line with increase of pro-opiomelanocortin (POMC) neuronal activities and decrease of agouti-related peptide (AgRP) neuronal activities. Furthermore, LE supplementation reduced hypothalamic endoplasmic reticulum (ER) stress which was stimulated in db/db mice. As ER stress is a crucial factor involving in appetite control and glucose homeostasis, the effect of LE supplementation on circulating glucose levels and feeding behavior might be mediated by suppression of hypothalamic ER stress. Collectively, these findings suggest that LE could be a potential nutraceutical for improvement of T2DM as well as patients with satiety issues.https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/fulllongantype 2 diabetesappetitebinge eating disorderER stressPOMC/AgRP |
| spellingShingle | Hyeyoon Eo Seong Hye Kim In Gyoung Ju Eugene Huh Sinyeon Kim Jin Gyu Choi Se Woong Kim Miwon Son Myung Sook Oh Myung Sook Oh Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice Frontiers in Nutrition longan type 2 diabetes appetite binge eating disorder ER stress POMC/AgRP |
| title | Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice |
| title_full | Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice |
| title_fullStr | Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice |
| title_full_unstemmed | Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice |
| title_short | Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice |
| title_sort | longan extract suppresses food intake through regulation of pomc agrp neuronal activities and endoplasmic reticulum stress in hypothalamus of db db mice |
| topic | longan type 2 diabetes appetite binge eating disorder ER stress POMC/AgRP |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1143613/full |
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