Data on the catalytic mechanism of thiol peroxidase mimics
We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H2O2), “The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with cyto...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916303250 |
| _version_ | 1818156050863357952 |
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| author | B. Zadehvakili N.M. Giles J.P. Fawcett G.I. Giles |
| author_facet | B. Zadehvakili N.M. Giles J.P. Fawcett G.I. Giles |
| author_sort | B. Zadehvakili |
| collection | DOAJ |
| description | We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H2O2), “The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action” B. Zadehvakili, S.M. McNeill, J.P. Fawcett, G.I. Giles (2016) [1]. This thiol peroxidase (TPx) activity is potentially useful for a number of therapeutic applications, as it can alter the outcome of oxidative stress related pathologies and modify redox signalling. This article presents data describing the molecular changes that occur to a TPx mimic upon exposure to H2O2, and then the thiol mercaptoethanol, as characterised by UV–vis spectroscopy and HPLC retention time. |
| first_indexed | 2024-12-11T14:52:08Z |
| format | Article |
| id | doaj.art-df1b4f3917434d9ba972df06129341e1 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T14:52:08Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-df1b4f3917434d9ba972df06129341e12022-12-22T01:01:25ZengElsevierData in Brief2352-34092016-09-018207210Data on the catalytic mechanism of thiol peroxidase mimicsB. Zadehvakili0N.M. Giles1J.P. Fawcett2G.I. Giles3School of Pharmacy, University of Otago, Dunedin, New ZealandDepartment of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New ZealandSchool of Pharmacy, University of Otago, Dunedin, New ZealandDepartment of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand; Correspondence to: Department of Pharmacology and Toxicology, University of Otago, P.O. Box 913, Dunedin, New Zealand. Tel.: +64 3 479 7322; fax: +64 3 479 9140.We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H2O2), “The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action” B. Zadehvakili, S.M. McNeill, J.P. Fawcett, G.I. Giles (2016) [1]. This thiol peroxidase (TPx) activity is potentially useful for a number of therapeutic applications, as it can alter the outcome of oxidative stress related pathologies and modify redox signalling. This article presents data describing the molecular changes that occur to a TPx mimic upon exposure to H2O2, and then the thiol mercaptoethanol, as characterised by UV–vis spectroscopy and HPLC retention time.http://www.sciencedirect.com/science/article/pii/S2352340916303250 |
| spellingShingle | B. Zadehvakili N.M. Giles J.P. Fawcett G.I. Giles Data on the catalytic mechanism of thiol peroxidase mimics Data in Brief |
| title | Data on the catalytic mechanism of thiol peroxidase mimics |
| title_full | Data on the catalytic mechanism of thiol peroxidase mimics |
| title_fullStr | Data on the catalytic mechanism of thiol peroxidase mimics |
| title_full_unstemmed | Data on the catalytic mechanism of thiol peroxidase mimics |
| title_short | Data on the catalytic mechanism of thiol peroxidase mimics |
| title_sort | data on the catalytic mechanism of thiol peroxidase mimics |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916303250 |
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