Dissecting the human microbiome with single-cell genomics
Editorial summary Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-06-01
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| Series: | Genome Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s13073-017-0448-7 |
| _version_ | 1818911289625280512 |
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| author | Andrew C. Tolonen Ramnik J. Xavier |
| author_facet | Andrew C. Tolonen Ramnik J. Xavier |
| author_sort | Andrew C. Tolonen |
| collection | DOAJ |
| description | Editorial summary Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the targeted study of immunogenic bacteria in disease. |
| first_indexed | 2024-12-19T22:56:20Z |
| format | Article |
| id | doaj.art-df1b7acc1fc542418dbb8dc12f2ad6ad |
| institution | Directory Open Access Journal |
| issn | 1756-994X |
| language | English |
| last_indexed | 2024-12-19T22:56:20Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Medicine |
| spelling | doaj.art-df1b7acc1fc542418dbb8dc12f2ad6ad2022-12-21T20:02:39ZengBMCGenome Medicine1756-994X2017-06-01911310.1186/s13073-017-0448-7Dissecting the human microbiome with single-cell genomicsAndrew C. Tolonen0Ramnik J. Xavier1Broad Institute of MIT and Harvard UniversityBroad Institute of MIT and Harvard UniversityEditorial summary Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the targeted study of immunogenic bacteria in disease.http://link.springer.com/article/10.1186/s13073-017-0448-7 |
| spellingShingle | Andrew C. Tolonen Ramnik J. Xavier Dissecting the human microbiome with single-cell genomics Genome Medicine |
| title | Dissecting the human microbiome with single-cell genomics |
| title_full | Dissecting the human microbiome with single-cell genomics |
| title_fullStr | Dissecting the human microbiome with single-cell genomics |
| title_full_unstemmed | Dissecting the human microbiome with single-cell genomics |
| title_short | Dissecting the human microbiome with single-cell genomics |
| title_sort | dissecting the human microbiome with single cell genomics |
| url | http://link.springer.com/article/10.1186/s13073-017-0448-7 |
| work_keys_str_mv | AT andrewctolonen dissectingthehumanmicrobiomewithsinglecellgenomics AT ramnikjxavier dissectingthehumanmicrobiomewithsinglecellgenomics |