Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes

Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes

Complexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'= isatin and HL= 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by equimolar reaction of a metal(...

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Bibliographic Details
Main Authors: Osman Souad A., Mousa Hanan A., Abdallah Yosef Hisham A., Hafez Taghrid S., El-Sawy Abdallah A., Abdallah Mohamed M., Hassan Ashraf S.
Format: Article
Language:English
Published: Serbian Chemical Society 2014-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
3-(2-(aryl)hydrazono)acetylacetone
isatin
transition metals
mixed ligands
cytotoxicity
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300134O.pdf
Description
Summary:Complexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'= isatin and HL= 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by equimolar reaction of a metal(II) chloride with isatin and 3-(2-(aryl)hydrazono)acetylacetone. The resulting complexes have been characterized by elemental analyses, molar conductivity, spectral data (IR, 1H NMR, mass) and magnetic moments. Furthermore, the ligands and their metal complexes have been screened for their cytotoxicity against different human cancer cell lines by using SRB assay. The results showed that most of the mixed ligand metal complexes have high cytotoxicity in comparison with the reference drugs used.
ISSN:0352-5139
1820-7421

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