Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes
Complexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'= isatin and HL= 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by equimolar reaction of a metal(...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2014-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300134O.pdf |
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| author | Osman Souad A. Mousa Hanan A. Abdallah Yosef Hisham A. Hafez Taghrid S. El-Sawy Abdallah A. Abdallah Mohamed M. Hassan Ashraf S. |
| author_facet | Osman Souad A. Mousa Hanan A. Abdallah Yosef Hisham A. Hafez Taghrid S. El-Sawy Abdallah A. Abdallah Mohamed M. Hassan Ashraf S. |
| author_sort | Osman Souad A. |
| collection | DOAJ |
| description | Complexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'=
isatin and HL= 3-(2-phenylhydrazono)acetylacetone,
3-(2-(4-chlorophenyl)hydrazono)acetylacetone or
3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by
equimolar reaction of a metal(II) chloride with isatin and
3-(2-(aryl)hydrazono)acetylacetone. The resulting complexes have been
characterized by elemental analyses, molar conductivity, spectral data (IR,
1H NMR, mass) and magnetic moments. Furthermore, the ligands and their metal
complexes have been screened for their cytotoxicity against different human
cancer cell lines by using SRB assay. The results showed that most of the
mixed ligand metal complexes have high cytotoxicity in comparison with the
reference drugs used. |
| first_indexed | 2024-04-13T03:31:04Z |
| format | Article |
| id | doaj.art-df1c24f6a7274bd09647c6bb732d5994 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-04-13T03:31:04Z |
| publishDate | 2014-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-df1c24f6a7274bd09647c6bb732d59942022-12-22T03:04:29ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212014-01-0179895396410.2298/JSC130813134O0352-51391300134OSynthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexesOsman Souad A.0Mousa Hanan A.1Abdallah Yosef Hisham A.2Hafez Taghrid S.3El-Sawy Abdallah A.4Abdallah Mohamed M.5Hassan Ashraf S.6Department of Organometallic and Organometalloid Chemistry, National Research Centre, Cairo, EgyptDepartment of Inorganic Chemistry, National Research Centre, Cairo, EgyptDepartment of Organometallic and Organometalloid Chemistry, National Research Centre, Cairo, EgyptDepartment of Organometallic and Organometalloid Chemistry, National Research Centre, Cairo, EgyptChemistry Department, Faculty of Science, Benha University, Benha, EgyptUnivet Pharmaceuticals Ltd, Balteem, EgyptDepartment of Organometallic and Organometalloid Chemistry, National Research Centre, Cairo, EgyptComplexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'= isatin and HL= 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by equimolar reaction of a metal(II) chloride with isatin and 3-(2-(aryl)hydrazono)acetylacetone. The resulting complexes have been characterized by elemental analyses, molar conductivity, spectral data (IR, 1H NMR, mass) and magnetic moments. Furthermore, the ligands and their metal complexes have been screened for their cytotoxicity against different human cancer cell lines by using SRB assay. The results showed that most of the mixed ligand metal complexes have high cytotoxicity in comparison with the reference drugs used.http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300134O.pdf3-(2-(aryl)hydrazono)acetylacetoneisatintransition metalsmixed ligandscytotoxicity |
| spellingShingle | Osman Souad A. Mousa Hanan A. Abdallah Yosef Hisham A. Hafez Taghrid S. El-Sawy Abdallah A. Abdallah Mohamed M. Hassan Ashraf S. Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes Journal of the Serbian Chemical Society 3-(2-(aryl)hydrazono)acetylacetone isatin transition metals mixed ligands cytotoxicity |
| title | Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes |
| title_full | Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes |
| title_fullStr | Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes |
| title_full_unstemmed | Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes |
| title_short | Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes |
| title_sort | synthesis characterization and cytotoxicity of mixed ligand mn ii co ii and ni ii complexes |
| topic | 3-(2-(aryl)hydrazono)acetylacetone isatin transition metals mixed ligands cytotoxicity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300134O.pdf |
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