Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy?
The optimal strategy for stimulation of young women with a low ovarian reserve is still a challenging issue because the physio-pathogeny of this disorder is often unknown. As androgen production by the ovary plays a crucial role in folliculogenesis, it was tempting to speculate that subtle perturbat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1231585/full |
| _version_ | 1797322257753702400 |
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| author | Jean Noel Hugues |
| author_facet | Jean Noel Hugues |
| author_sort | Jean Noel Hugues |
| collection | DOAJ |
| description | The optimal strategy for stimulation of young women with a low ovarian reserve is still a challenging issue because the physio-pathogeny of this disorder is often unknown. As androgen production by the ovary plays a crucial role in folliculogenesis, it was tempting to speculate that subtle perturbations in ovarian steroidogenesis might participate to the low responsiveness to gonadotrophins. Indeed, in vitro analysis of human luteinized granulosa cells has recently provided evidence for some enzymatic deficits in steroidogenesis and altered response to gonadotrophins. Therefore, improving androgen environment of women classified in Poseidon Group 3 should be considered. In this clinical situation, the potential benefit of androgen supplementation or stimulation of theca cells by LH-activity products are respectively discussed. |
| first_indexed | 2024-03-08T05:11:37Z |
| format | Article |
| id | doaj.art-df1cf52bf86e429a8a5ec6b6bd80b991 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T05:11:37Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-df1cf52bf86e429a8a5ec6b6bd80b9912024-02-07T09:20:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.12315851231585Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy?Jean Noel HuguesThe optimal strategy for stimulation of young women with a low ovarian reserve is still a challenging issue because the physio-pathogeny of this disorder is often unknown. As androgen production by the ovary plays a crucial role in folliculogenesis, it was tempting to speculate that subtle perturbations in ovarian steroidogenesis might participate to the low responsiveness to gonadotrophins. Indeed, in vitro analysis of human luteinized granulosa cells has recently provided evidence for some enzymatic deficits in steroidogenesis and altered response to gonadotrophins. Therefore, improving androgen environment of women classified in Poseidon Group 3 should be considered. In this clinical situation, the potential benefit of androgen supplementation or stimulation of theca cells by LH-activity products are respectively discussed.https://www.frontiersin.org/articles/10.3389/fendo.2024.1231585/fullovarian physiologyandrogen -anti-Mullerian hormone (AMH)folliculogenesissteroid biosynthesis |
| spellingShingle | Jean Noel Hugues Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? Frontiers in Endocrinology ovarian physiology androgen - anti-Mullerian hormone (AMH) folliculogenesis steroid biosynthesis |
| title | Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? |
| title_full | Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? |
| title_fullStr | Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? |
| title_full_unstemmed | Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? |
| title_short | Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? |
| title_sort | subtle perturbations of ovarian steroidogenesis in patients classified as poseidon group 3 which consequences for therapeutic strategy |
| topic | ovarian physiology androgen - anti-Mullerian hormone (AMH) folliculogenesis steroid biosynthesis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1231585/full |
| work_keys_str_mv | AT jeannoelhugues subtleperturbationsofovariansteroidogenesisinpatientsclassifiedasposeidongroup3whichconsequencesfortherapeuticstrategy |