Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes
Cuproptosis is a novel kind of programmed cell death that has been linked to tumor development, prognosis, and responsiveness to therapy. Nevertheless, the precise function of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) remains unknown. We characterized the genetic and trans...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.910928/full |
| _version_ | 1797997438956470272 |
|---|---|
| author | Chiyu Zhang Ruizhen Huang Xiaoqing Xi |
| author_facet | Chiyu Zhang Ruizhen Huang Xiaoqing Xi |
| author_sort | Chiyu Zhang |
| collection | DOAJ |
| description | Cuproptosis is a novel kind of programmed cell death that has been linked to tumor development, prognosis, and responsiveness to therapy. Nevertheless, the precise function of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) remains unknown. We characterized the genetic and transcriptional changes of CRGs in papillary renal cell carcinoma (PRCC) samples and analyzed the expression patterns in two separate cohorts. We observed that two unique cuproptosis-related subgroups and three separate gene subgroups were connected with clinicopathological, prognostic, and TME features of patients. Then, a risk score for predicting overall survival (OS) was created and validated in patients with PRCC. To make the risk score more clinically useful, we created a nomogram that was very accurate. A lower risk score, which was associated with higher tumor mutation burden, and immune activity, suggested a better prognosis for OS. Additionally, the risk score was shown to be substantially linked with the drug’s susceptibility to chemotherapeutic agents. Our extensive research of CRGs in PRCC identified possible roles for them in the TME, clinicopathological features, and overall survival. These findings may help advance our knowledge of CRGs in PRCC and pave the way for improved prognosis and the creation of more effective immunotherapy therapies. |
| first_indexed | 2024-04-11T10:32:59Z |
| format | Article |
| id | doaj.art-df1d0b8ef6b74e6988db84fd51d1ffb4 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T10:32:59Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-df1d0b8ef6b74e6988db84fd51d1ffb42022-12-22T04:29:23ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-10-01910.3389/fmolb.2022.910928910928Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapesChiyu ZhangRuizhen HuangXiaoqing XiCuproptosis is a novel kind of programmed cell death that has been linked to tumor development, prognosis, and responsiveness to therapy. Nevertheless, the precise function of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) remains unknown. We characterized the genetic and transcriptional changes of CRGs in papillary renal cell carcinoma (PRCC) samples and analyzed the expression patterns in two separate cohorts. We observed that two unique cuproptosis-related subgroups and three separate gene subgroups were connected with clinicopathological, prognostic, and TME features of patients. Then, a risk score for predicting overall survival (OS) was created and validated in patients with PRCC. To make the risk score more clinically useful, we created a nomogram that was very accurate. A lower risk score, which was associated with higher tumor mutation burden, and immune activity, suggested a better prognosis for OS. Additionally, the risk score was shown to be substantially linked with the drug’s susceptibility to chemotherapeutic agents. Our extensive research of CRGs in PRCC identified possible roles for them in the TME, clinicopathological features, and overall survival. These findings may help advance our knowledge of CRGs in PRCC and pave the way for improved prognosis and the creation of more effective immunotherapy therapies.https://www.frontiersin.org/articles/10.3389/fmolb.2022.910928/fullcuproptosispapillary renal cell carcinomatumor microenvironmentdrug sensitivityprognostic model |
| spellingShingle | Chiyu Zhang Ruizhen Huang Xiaoqing Xi Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes Frontiers in Molecular Biosciences cuproptosis papillary renal cell carcinoma tumor microenvironment drug sensitivity prognostic model |
| title | Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| title_full | Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| title_fullStr | Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| title_full_unstemmed | Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| title_short | Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| title_sort | cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes |
| topic | cuproptosis papillary renal cell carcinoma tumor microenvironment drug sensitivity prognostic model |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.910928/full |
| work_keys_str_mv | AT chiyuzhang cuproptosispatternsinpapillaryrenalcellcarcinomaarecharacterizedbydistincttumormicroenvironmentinfiltrationlandscapes AT ruizhenhuang cuproptosispatternsinpapillaryrenalcellcarcinomaarecharacterizedbydistincttumormicroenvironmentinfiltrationlandscapes AT xiaoqingxi cuproptosispatternsinpapillaryrenalcellcarcinomaarecharacterizedbydistincttumormicroenvironmentinfiltrationlandscapes |