Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
Abstract INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2020-03-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100629&tlng=en |
| _version_ | 1811245522235686912 |
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| author | Adalid Palma Gabriela Matamoros Denis Escobar Ana Lourdes Sánchez Gustavo Fontecha |
| author_facet | Adalid Palma Gabriela Matamoros Denis Escobar Ana Lourdes Sánchez Gustavo Fontecha |
| author_sort | Adalid Palma |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced. RESULTS: All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene. CONCLUSIONS: This is the first report of genetic sequences associated with benzimidazole resistance in A. suum. |
| first_indexed | 2024-04-12T14:41:06Z |
| format | Article |
| id | doaj.art-df1d58eb723548438b3f72fe50a91346 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:41:06Z |
| publishDate | 2020-03-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-df1d58eb723548438b3f72fe50a913462022-12-22T03:28:52ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-03-015310.1590/0037-8682-0155-2019Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suumAdalid PalmaGabriela MatamorosDenis EscobarAna Lourdes SánchezGustavo Fontechahttps://orcid.org/0000-0001-9756-4520Abstract INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced. RESULTS: All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene. CONCLUSIONS: This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100629&tlng=enAscaris suumBenzimidazoleBeta-tubulin gene |
| spellingShingle | Adalid Palma Gabriela Matamoros Denis Escobar Ana Lourdes Sánchez Gustavo Fontecha Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum Revista da Sociedade Brasileira de Medicina Tropical Ascaris suum Benzimidazole Beta-tubulin gene |
| title | Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum |
| title_full | Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum |
| title_fullStr | Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum |
| title_full_unstemmed | Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum |
| title_short | Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum |
| title_sort | absence of mutations associated with resistance to benzimidazole in the beta tubulin gene of ascaris suum |
| topic | Ascaris suum Benzimidazole Beta-tubulin gene |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100629&tlng=en |
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