Altered Expression Pattern of Topoisomerase IIα, in Ovarian Tumor Epithelial and Stromal Cells after Platinum-Based Chemotherapy

Altered Expression Pattern of Topoisomerase IIα, in Ovarian Tumor Epithelial and Stromal Cells after Platinum-Based Chemotherapy

OBJECTIVE: The aim of this study was to evaluate the expression of topoisomerase IIα (TOP2A) in epithelial and stromal cells of ovarian cancer. METHODS: TOP2A expression was analyzed in normal ovarian tissue and in laser-microdissected ovarian tumor epithelial and adjacent stromal cells using quanti...

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Bibliographic Details
Main Authors: Radoslav Chekerov, Irina Klaman, Menelaos Zafrakas, Dominique Könsgen, Alexander Mustea, Beate Petschke, Werner Lichtenegger, Jalid Sehouli, Edgar Dahl
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TOP2A
ovarian cancer
RNA in situ hybridization
tumor stromal cells
chemotherapy resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800394

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http://www.sciencedirect.com/science/article/pii/S1476558606800394

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