Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms
This article provides a succinct but limited overview of the protective and deleterious effects of reactive oxygen and nitrogen species in a clinical context. Reactive oxygen species include superoxide, hydrogen peroxide, single oxygen and lipid peroxides. Reactive nitrogen species include species d...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231713000359 |
| _version_ | 1818756196652285952 |
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| author | Balaraman Kalyanaraman |
| author_facet | Balaraman Kalyanaraman |
| author_sort | Balaraman Kalyanaraman |
| collection | DOAJ |
| description | This article provides a succinct but limited overview of the protective and deleterious effects of reactive oxygen and nitrogen species in a clinical context. Reactive oxygen species include superoxide, hydrogen peroxide, single oxygen and lipid peroxides. Reactive nitrogen species include species derived from nitric oxide. This review gives a brief overview of the reaction chemistry of these species, the role of various enzymes involved in the generation and detoxification of these species in disease mechanisms and drug toxicity and the protective role of dietary antioxidants. I hope that the graphical review will be helpful for teaching both the first year medical and graduate students in the U.S. and abroad the fundamentals of reactive oxygen and nitrogen species in redox biology and clinical medicine. |
| first_indexed | 2024-12-18T05:51:12Z |
| format | Article |
| id | doaj.art-df1f76a32a224e8bb0d5fb33656c0cd7 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-18T05:51:12Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-df1f76a32a224e8bb0d5fb33656c0cd72022-12-21T21:18:54ZengElsevierRedox Biology2213-23172013-01-011124425710.1016/j.redox.2013.01.014Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanismsBalaraman KalyanaramanThis article provides a succinct but limited overview of the protective and deleterious effects of reactive oxygen and nitrogen species in a clinical context. Reactive oxygen species include superoxide, hydrogen peroxide, single oxygen and lipid peroxides. Reactive nitrogen species include species derived from nitric oxide. This review gives a brief overview of the reaction chemistry of these species, the role of various enzymes involved in the generation and detoxification of these species in disease mechanisms and drug toxicity and the protective role of dietary antioxidants. I hope that the graphical review will be helpful for teaching both the first year medical and graduate students in the U.S. and abroad the fundamentals of reactive oxygen and nitrogen species in redox biology and clinical medicine.http://www.sciencedirect.com/science/article/pii/S2213231713000359Reactive oxygen speciesReperfusion injurySuperoxidePeroxynitrite |
| spellingShingle | Balaraman Kalyanaraman Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms Redox Biology Reactive oxygen species Reperfusion injury Superoxide Peroxynitrite |
| title | Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms |
| title_full | Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms |
| title_fullStr | Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms |
| title_full_unstemmed | Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms |
| title_short | Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms |
| title_sort | teaching the basics of redox biology to medical and graduate students oxidants antioxidants and disease mechanisms |
| topic | Reactive oxygen species Reperfusion injury Superoxide Peroxynitrite |
| url | http://www.sciencedirect.com/science/article/pii/S2213231713000359 |
| work_keys_str_mv | AT balaramankalyanaraman teachingthebasicsofredoxbiologytomedicalandgraduatestudentsoxidantsantioxidantsanddiseasemechanisms |