High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy
The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301128 |
| _version_ | 1811299245138903040 |
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| author | Tamar M. van Veenendaal Walter H. Backes Desmond H.Y. Tse Tom W.J. Scheenen Dennis W. Klomp Paul A.M. Hofman Rob P.W. Rouhl Marielle C.G. Vlooswijk Albert P. Aldenkamp Jacobus F.A. Jansen |
| author_facet | Tamar M. van Veenendaal Walter H. Backes Desmond H.Y. Tse Tom W.J. Scheenen Dennis W. Klomp Paul A.M. Hofman Rob P.W. Rouhl Marielle C.G. Vlooswijk Albert P. Aldenkamp Jacobus F.A. Jansen |
| author_sort | Tamar M. van Veenendaal |
| collection | DOAJ |
| description | The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0 T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the ‘neurotransmitter networks’ concept might also provide new insights for other neurological diseases. Keywords: GABA, Glutamate, MR spectroscopic imaging, Networks, 7T |
| first_indexed | 2024-04-13T06:32:22Z |
| format | Article |
| id | doaj.art-df21a181e762452caf6111934c840b7c |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T06:32:22Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-df21a181e762452caf6111934c840b7c2022-12-22T02:58:05ZengElsevierNeuroImage: Clinical2213-15822018-01-01194755High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsyTamar M. van Veenendaal0Walter H. Backes1Desmond H.Y. Tse2Tom W.J. Scheenen3Dennis W. Klomp4Paul A.M. Hofman5Rob P.W. Rouhl6Marielle C.G. Vlooswijk7Albert P. Aldenkamp8Jacobus F.A. Jansen9Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), The Netherlands; School for Mental Health and Neuroscience, Maastricht University, The NetherlandsDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), The Netherlands; School for Mental Health and Neuroscience, Maastricht University, The NetherlandsDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), The Netherlands; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The NetherlandsDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Radiology, University Medical Center Utrecht, Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), The Netherlands; School for Mental Health and Neuroscience, Maastricht University, The Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+, Heeze and Maastricht, The NetherlandsSchool for Mental Health and Neuroscience, Maastricht University, The Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+, Heeze and Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Center, The NetherlandsSchool for Mental Health and Neuroscience, Maastricht University, The Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+, Heeze and Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Center, The NetherlandsSchool for Mental Health and Neuroscience, Maastricht University, The Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+, Heeze and Maastricht, The Netherlands; Department of Neurology, Maastricht University Medical Center, The NetherlandsDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), The Netherlands; School for Mental Health and Neuroscience, Maastricht University, The Netherlands; Corresponding author at: Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0 T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the ‘neurotransmitter networks’ concept might also provide new insights for other neurological diseases. Keywords: GABA, Glutamate, MR spectroscopic imaging, Networks, 7Thttp://www.sciencedirect.com/science/article/pii/S2213158218301128 |
| spellingShingle | Tamar M. van Veenendaal Walter H. Backes Desmond H.Y. Tse Tom W.J. Scheenen Dennis W. Klomp Paul A.M. Hofman Rob P.W. Rouhl Marielle C.G. Vlooswijk Albert P. Aldenkamp Jacobus F.A. Jansen High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy NeuroImage: Clinical |
| title | High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy |
| title_full | High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy |
| title_fullStr | High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy |
| title_full_unstemmed | High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy |
| title_short | High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy |
| title_sort | high field imaging of large scale neurotransmitter networks proof of concept and initial application to epilepsy |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301128 |
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