Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells

Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells

Summary: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a progressive increase in pulmonary artery pressure caused by pathological pulmonary artery remodeling. Here, we demonstrate that endothelial cell (EC) senescence plays a negative role in pulmonary hypertension via ju...

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Bibliographic Details
Main Authors: Risa Ramadhiani, Koji Ikeda, Kazuya Miyagawa, Gusty Rizky Tough Ryanto, Naoki Tamada, Yoko Suzuki, Yuhei Kirita, Satoaki Matoba, Ken-ichi Hirata, Noriaki Emoto
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007393

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223007393

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