Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/13/3970 |
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| author | Roberto Fernández-Acosta Claudia Iriarte-Mesa Daniel Alvarez-Alminaque Behrouz Hassannia Bartosz Wiernicki Alicia M. Díaz-García Peter Vandenabeele Tom Vanden Berghe Gilberto L. Pardo Andreu |
| author_facet | Roberto Fernández-Acosta Claudia Iriarte-Mesa Daniel Alvarez-Alminaque Behrouz Hassannia Bartosz Wiernicki Alicia M. Díaz-García Peter Vandenabeele Tom Vanden Berghe Gilberto L. Pardo Andreu |
| author_sort | Roberto Fernández-Acosta |
| collection | DOAJ |
| description | The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation. |
| first_indexed | 2024-03-09T04:01:56Z |
| format | Article |
| id | doaj.art-df22e7564846462d95dc944b4561cd8a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:01:56Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-df22e7564846462d95dc944b4561cd8a2023-12-03T14:12:40ZengMDPI AGMolecules1420-30492022-06-012713397010.3390/molecules27133970Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell LinesRoberto Fernández-Acosta0Claudia Iriarte-Mesa1Daniel Alvarez-Alminaque2Behrouz Hassannia3Bartosz Wiernicki4Alicia M. Díaz-García5Peter Vandenabeele6Tom Vanden Berghe7Gilberto L. Pardo Andreu8Department of Pharmacy, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 Street # 2317, La Coronela, La Lisa, Havana 13600, CubaLaboratory of Bioinorganic (LBI), Department of Inorganic and General Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Vedado, Plaza de la Revolución, Havana 10400, CubaCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 Street # 2317, La Coronela, La Lisa, Havana 13600, CubaVIB Center for Inflammation Research (IRC), 9052 Ghent, BelgiumVIB Center for Inflammation Research (IRC), 9052 Ghent, BelgiumLaboratory of Bioinorganic (LBI), Department of Inorganic and General Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Vedado, Plaza de la Revolución, Havana 10400, CubaVIB Center for Inflammation Research (IRC), 9052 Ghent, BelgiumVIB Center for Inflammation Research (IRC), 9052 Ghent, BelgiumCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 Street # 2317, La Coronela, La Lisa, Havana 13600, CubaThe use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.https://www.mdpi.com/1420-3049/27/13/3970IONP–GA/PAAferroptosiscancer cells |
| spellingShingle | Roberto Fernández-Acosta Claudia Iriarte-Mesa Daniel Alvarez-Alminaque Behrouz Hassannia Bartosz Wiernicki Alicia M. Díaz-García Peter Vandenabeele Tom Vanden Berghe Gilberto L. Pardo Andreu Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines Molecules IONP–GA/PAA ferroptosis cancer cells |
| title | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
| title_full | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
| title_fullStr | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
| title_full_unstemmed | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
| title_short | Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines |
| title_sort | novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines |
| topic | IONP–GA/PAA ferroptosis cancer cells |
| url | https://www.mdpi.com/1420-3049/27/13/3970 |
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