Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Abstract Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Biological Research |
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| Online Access: | https://doi.org/10.1186/s40659-024-00490-5 |
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| author | Elisa Perez-Moreno Claudia Oyanadel Adely de la Peña Ronny Hernández Francisca Pérez-Molina Claudia Metz Alfonso González Andrea Soza |
| author_facet | Elisa Perez-Moreno Claudia Oyanadel Adely de la Peña Ronny Hernández Francisca Pérez-Molina Claudia Metz Alfonso González Andrea Soza |
| author_sort | Elisa Perez-Moreno |
| collection | DOAJ |
| description | Abstract Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts. |
| first_indexed | 2024-04-24T12:43:05Z |
| format | Article |
| id | doaj.art-df23293857b64f45997a3367296483e3 |
| institution | Directory Open Access Journal |
| issn | 0717-6287 |
| language | English |
| last_indexed | 2024-04-24T12:43:05Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-df23293857b64f45997a3367296483e32024-04-07T11:08:54ZengBMCBiological Research0717-62872024-04-0157111810.1186/s40659-024-00490-5Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasisElisa Perez-Moreno0Claudia Oyanadel1Adely de la Peña2Ronny Hernández3Francisca Pérez-Molina4Claudia Metz5Alfonso González6Andrea Soza7Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San SebastiánAbstract Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts.https://doi.org/10.1186/s40659-024-00490-5EMTGalectinCancerMetastasisTissue repairFibrosis |
| spellingShingle | Elisa Perez-Moreno Claudia Oyanadel Adely de la Peña Ronny Hernández Francisca Pérez-Molina Claudia Metz Alfonso González Andrea Soza Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis Biological Research EMT Galectin Cancer Metastasis Tissue repair Fibrosis |
| title | Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis |
| title_full | Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis |
| title_fullStr | Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis |
| title_full_unstemmed | Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis |
| title_short | Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis |
| title_sort | galectins in epithelial mesenchymal transition roles and mechanisms contributing to tissue repair fibrosis and cancer metastasis |
| topic | EMT Galectin Cancer Metastasis Tissue repair Fibrosis |
| url | https://doi.org/10.1186/s40659-024-00490-5 |
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