Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age
The identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. The aim of this study was to evaluate the relationship between cord blood interleukin-13 (IL-13) and interferon-gamma (IFN-γ) and development of allergic diseases...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-06-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/525 |
| _version_ | 1818521925422415872 |
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| author | Nevin Uzuner Arzu Babayigit Hocaoglu Duygu Olmez Erge Suna Asilsoy Ozkan Karaman Zekiye Altun Abdullah Kumral Ozlem Tufekci Huray Islekel |
| author_facet | Nevin Uzuner Arzu Babayigit Hocaoglu Duygu Olmez Erge Suna Asilsoy Ozkan Karaman Zekiye Altun Abdullah Kumral Ozlem Tufekci Huray Islekel |
| author_sort | Nevin Uzuner |
| collection | DOAJ |
| description | The identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. The aim of this study was to evaluate the relationship between cord blood interleukin-13 (IL-13) and interferon-gamma (IFN-γ) and development of allergic diseases during the first five years of life. Umbilical cord blood samples were collected at the time of delivery from 62 newborns. The families of these newborns were asked to complete a questionnaire about age and education of parents, number of siblings, allergic diseases in family members, cigarette exposure during pregnancy and presence of pets in their house. The same subjects were evaluated when they were five years old. Venous blood samples were drawn and epidermal skin prick tests were performed. IL-13 and interferon-gamma (IFN-γ) levels were studied from the blood samples which were taken during birth and five years later. There was no significant relationship between gender, type of delivery, educational levels of parents, exposure to cigarette smoke, atopy in parents, presence of pets in the house and IL-13 and IFN-γ levels in cord blood and at five years. Higher levels of IL-13 in newborns and five years olds, were found significantly related to skin prick test positivity (p=0.004 and p<0.0001, respectively) and presence of allergic diseases (p= 0.008 and p= 0.001, respectively). Levels of IFN-γ, both in cord blood and five years after, were not related with the future of allergic status of children. Higher levels of IL-13 in cord blood may be a predictor of future development of allergic sensitization. |
| first_indexed | 2024-12-11T01:57:53Z |
| format | Article |
| id | doaj.art-df23aea79fd445d2be9854cd01af79db |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-11T01:57:53Z |
| publishDate | 2013-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-df23aea79fd445d2be9854cd01af79db2022-12-22T01:24:33ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492013-06-01122490Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of AgeNevin Uzuner0Arzu Babayigit Hocaoglu1Duygu Olmez Erge2Suna Asilsoy3Ozkan Karaman4Zekiye Altun5Abdullah Kumral6Ozlem Tufekci7Huray Islekel8Dokuz Eylul University Hospital, Department of Pediatric Allergy, 35340, Balcova, Izmir, Turkey.Dokuz Eylul University Hospital, Department of Pediatric Allergy, 35340, Balcova, Izmir, Turkey.Dokuz Eylul University Hospital, Department of Pediatric Allergy, 35340, Balcova, Izmir, Turkey.Baskent University Hospital, Department of Pediatric Allergy, Adana, TurkeyDokuz Eylul University Hospital, Department of Pediatric Allergy, 35340, Balcova, Izmir, Turkey.Dokuz Eylul University Hospital, Department of Biochemistry, 35340, Balcova, Izmir, TurkeyDokuz Eylul University Hospital, Department of Neonatology, 35340, Balcova, Izmir, TurkeyDokuz Eylul University Hospital, Department of Pediatric Allergy, 35340, Balcova, Izmir, Turkey.Dokuz Eylul University Hospital, Department of Biochemistry, 35340, Balcova, Izmir, TurkeyThe identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. The aim of this study was to evaluate the relationship between cord blood interleukin-13 (IL-13) and interferon-gamma (IFN-γ) and development of allergic diseases during the first five years of life. Umbilical cord blood samples were collected at the time of delivery from 62 newborns. The families of these newborns were asked to complete a questionnaire about age and education of parents, number of siblings, allergic diseases in family members, cigarette exposure during pregnancy and presence of pets in their house. The same subjects were evaluated when they were five years old. Venous blood samples were drawn and epidermal skin prick tests were performed. IL-13 and interferon-gamma (IFN-γ) levels were studied from the blood samples which were taken during birth and five years later. There was no significant relationship between gender, type of delivery, educational levels of parents, exposure to cigarette smoke, atopy in parents, presence of pets in the house and IL-13 and IFN-γ levels in cord blood and at five years. Higher levels of IL-13 in newborns and five years olds, were found significantly related to skin prick test positivity (p=0.004 and p<0.0001, respectively) and presence of allergic diseases (p= 0.008 and p= 0.001, respectively). Levels of IFN-γ, both in cord blood and five years after, were not related with the future of allergic status of children. Higher levels of IL-13 in cord blood may be a predictor of future development of allergic sensitization.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/525AllergyCord bloodInterferon-gammaInterleukin-13 |
| spellingShingle | Nevin Uzuner Arzu Babayigit Hocaoglu Duygu Olmez Erge Suna Asilsoy Ozkan Karaman Zekiye Altun Abdullah Kumral Ozlem Tufekci Huray Islekel Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age Iranian Journal of Allergy, Asthma and Immunology Allergy Cord blood Interferon-gamma Interleukin-13 |
| title | Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age |
| title_full | Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age |
| title_fullStr | Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age |
| title_full_unstemmed | Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age |
| title_short | Raised Interleukin-13 Levels in Cord Blood Increases the Risk of Allergic Sensitization at 5 Years of Age |
| title_sort | raised interleukin 13 levels in cord blood increases the risk of allergic sensitization at 5 years of age |
| topic | Allergy Cord blood Interferon-gamma Interleukin-13 |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/525 |
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