Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants
Background: Fast disintegrating tablet (FDT) of ondansetron has better patient compliance as it is easy to swallow for the treatment of nausea and vomiting. Moreover, fast absorption, rapid onset, reduced loss of drugs, and enhanced bioavailability are making oral dispersible systems a better drug...
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| Format: | Article |
| Language: | English |
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Karnali Academy of Health Sciences
2023-08-01
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| Series: | Journal of Karnali Academy of Health Sciences |
| Subjects: | |
| Online Access: | http://jkahs.org.np/jkahs/index.php/jkahs/article/view/717 |
| _version_ | 1797644107564187648 |
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| author | Asha Maharjan Keerthy HS Kulkarni Gururaj S. Sheeba FR Sitaram Khadka |
| author_facet | Asha Maharjan Keerthy HS Kulkarni Gururaj S. Sheeba FR Sitaram Khadka |
| author_sort | Asha Maharjan |
| collection | DOAJ |
| description |
Background: Fast disintegrating tablet (FDT) of ondansetron has better patient compliance as it is easy to swallow for the treatment of nausea and vomiting. Moreover, fast absorption, rapid onset, reduced loss of drugs, and enhanced bioavailability are making oral dispersible systems a better drug delivery system. This research was conducted with the objective to formulate and evaluate the oral FDT of ondansetron HCl using natural polymers.
Methods: The tablets were formulated employing the direct compression technique using different ratios of natural super disintegrants such as spray-dried banana powder, ispaghula husk powder, and combination of both polymers. The developed powders were subjected to the pre-compression parameters and the powders were punched using a single-head rotatory compression machine. The formulated 200 mg tablets were subjected to post-compression evaluation.
Results: The Fourier-transform infrared spectroscopy studies showed no chemical interaction between pure drugs, natural super disintegrants, and other excipients. Formulation F6 containing ispaghula husk powder in a 1:4 ratio demonstrated 98.60±0.003% of drug release within 10 minutes indicating the best formulation.
Conclusion: FDT of ondansetron was considered the best formulation in the drug delivery system which followed the Higuchi model with the Fickian release.
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| first_indexed | 2024-03-11T14:25:40Z |
| format | Article |
| id | doaj.art-df26f618afa1446eb889382161045ca6 |
| institution | Directory Open Access Journal |
| issn | 2616-0064 2676-1327 |
| language | English |
| last_indexed | 2024-03-11T14:25:40Z |
| publishDate | 2023-08-01 |
| publisher | Karnali Academy of Health Sciences |
| record_format | Article |
| series | Journal of Karnali Academy of Health Sciences |
| spelling | doaj.art-df26f618afa1446eb889382161045ca62023-10-31T15:30:14ZengKarnali Academy of Health SciencesJournal of Karnali Academy of Health Sciences2616-00642676-13272023-08-0162865Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural SuperdisintegrantsAsha Maharjan0Keerthy HS 1Kulkarni Gururaj S.Sheeba FRSitaram KhadkaRajiv Gandhi University of Health Science, Banglore, IndiaRajiv Gandhi University of Health Sciences Background: Fast disintegrating tablet (FDT) of ondansetron has better patient compliance as it is easy to swallow for the treatment of nausea and vomiting. Moreover, fast absorption, rapid onset, reduced loss of drugs, and enhanced bioavailability are making oral dispersible systems a better drug delivery system. This research was conducted with the objective to formulate and evaluate the oral FDT of ondansetron HCl using natural polymers. Methods: The tablets were formulated employing the direct compression technique using different ratios of natural super disintegrants such as spray-dried banana powder, ispaghula husk powder, and combination of both polymers. The developed powders were subjected to the pre-compression parameters and the powders were punched using a single-head rotatory compression machine. The formulated 200 mg tablets were subjected to post-compression evaluation. Results: The Fourier-transform infrared spectroscopy studies showed no chemical interaction between pure drugs, natural super disintegrants, and other excipients. Formulation F6 containing ispaghula husk powder in a 1:4 ratio demonstrated 98.60±0.003% of drug release within 10 minutes indicating the best formulation. Conclusion: FDT of ondansetron was considered the best formulation in the drug delivery system which followed the Higuchi model with the Fickian release. http://jkahs.org.np/jkahs/index.php/jkahs/article/view/717OndansetronAntiemeticsFast disintegrating tabletsPharmaceutics |
| spellingShingle | Asha Maharjan Keerthy HS Kulkarni Gururaj S. Sheeba FR Sitaram Khadka Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants Journal of Karnali Academy of Health Sciences Ondansetron Antiemetics Fast disintegrating tablets Pharmaceutics |
| title | Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants |
| title_full | Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants |
| title_fullStr | Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants |
| title_full_unstemmed | Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants |
| title_short | Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants |
| title_sort | formulation and evaluation of fast disintegrating tablets of ondansetron using natural superdisintegrants |
| topic | Ondansetron Antiemetics Fast disintegrating tablets Pharmaceutics |
| url | http://jkahs.org.np/jkahs/index.php/jkahs/article/view/717 |
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