Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3795 |
| _version_ | 1827689106522505216 |
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| author | James N. Tsoporis Ioannis-Alexandros Drosatos Sahil Gupta Hajera Amatullah Shehla Izhar Claudia C. dos Santos Vasileos Salpeas Angelos G. Rigopoulos Ioannis K. Toumpoulis Andreas S. Triantafyllis Eleftharios Sakadakis Nikolaos Kavantzas John C. Marshall Ioannis K. Rizos Thomas G. Parker |
| author_facet | James N. Tsoporis Ioannis-Alexandros Drosatos Sahil Gupta Hajera Amatullah Shehla Izhar Claudia C. dos Santos Vasileos Salpeas Angelos G. Rigopoulos Ioannis K. Toumpoulis Andreas S. Triantafyllis Eleftharios Sakadakis Nikolaos Kavantzas John C. Marshall Ioannis K. Rizos Thomas G. Parker |
| author_sort | James N. Tsoporis |
| collection | DOAJ |
| description | DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease. |
| first_indexed | 2024-03-10T10:11:09Z |
| format | Article |
| id | doaj.art-df27567a4de645a8a6c0bfed11cfa0f4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:11:09Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-df27567a4de645a8a6c0bfed11cfa0f42023-11-22T01:12:12ZengMDPI AGMolecules1420-30492021-06-012613379510.3390/molecules26133795Cytoprotective Mechanisms of DJ-1: Implications in Cardiac PathophysiologyJames N. Tsoporis0Ioannis-Alexandros Drosatos1Sahil Gupta2Hajera Amatullah3Shehla Izhar4Claudia C. dos Santos5Vasileos Salpeas6Angelos G. Rigopoulos7Ioannis K. Toumpoulis8Andreas S. Triantafyllis9Eleftharios Sakadakis10Nikolaos Kavantzas11John C. Marshall12Ioannis K. Rizos13Thomas G. Parker14Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, GreeceKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, CanadaGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02210, USAKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, CanadaKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, GreeceKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, GreeceKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, CanadaDJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease.https://www.mdpi.com/1420-3049/26/13/3795DJ-1antioxidantheart failureapoptosisinflammation |
| spellingShingle | James N. Tsoporis Ioannis-Alexandros Drosatos Sahil Gupta Hajera Amatullah Shehla Izhar Claudia C. dos Santos Vasileos Salpeas Angelos G. Rigopoulos Ioannis K. Toumpoulis Andreas S. Triantafyllis Eleftharios Sakadakis Nikolaos Kavantzas John C. Marshall Ioannis K. Rizos Thomas G. Parker Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology Molecules DJ-1 antioxidant heart failure apoptosis inflammation |
| title | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
| title_full | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
| title_fullStr | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
| title_full_unstemmed | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
| title_short | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
| title_sort | cytoprotective mechanisms of dj 1 implications in cardiac pathophysiology |
| topic | DJ-1 antioxidant heart failure apoptosis inflammation |
| url | https://www.mdpi.com/1420-3049/26/13/3795 |
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