Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea
Loquat (Eriobotrya japonica) leaves have been used as traditional medicine for chemoprevention and treatment of chronic inflammatory diseases although the evidence supporting their functions is still poor. This study aims to clarify the anti-inflammatory effects and molecular mechanisms of loquat te...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613002879 |
| _version_ | 1818592009637593088 |
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| author | Phyu Phyu Khine Zar Akiko Morishita Fumio Hashimoto Kozue Sakao Makoto Fujii Koji Wada De-Xing Hou |
| author_facet | Phyu Phyu Khine Zar Akiko Morishita Fumio Hashimoto Kozue Sakao Makoto Fujii Koji Wada De-Xing Hou |
| author_sort | Phyu Phyu Khine Zar |
| collection | DOAJ |
| description | Loquat (Eriobotrya japonica) leaves have been used as traditional medicine for chemoprevention and treatment of chronic inflammatory diseases although the evidence supporting their functions is still poor. This study aims to clarify the anti-inflammatory effects and molecular mechanisms of loquat tea extract (LTE), in both cell and animal models. LTE, especially C fraction, inhibited the production of pro-inflammatory factors including inducible nitric oxide synthase (iNOS), nitric oxide (NO), IL-6, RANTES and TNF-α. Cellular signaling data revealed that the downregulation of TGF-β-activated kinase (TAK1)-mediated both mitogen-activated protein kinase (MAPK) and NF-κB pathways were involved in the inhibition of pro-inflammatory factors by C fraction. Mouse paws edema model further confirmed the in vivo anti-inflammatory effects of LTE. |
| first_indexed | 2024-12-16T10:21:31Z |
| format | Article |
| id | doaj.art-df285625b79148a6b6d8ed6b33a2eb38 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T10:21:31Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-df285625b79148a6b6d8ed6b33a2eb382022-12-21T22:35:18ZengElsevierJournal of Functional Foods1756-46462014-01-016523533Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) teaPhyu Phyu Khine Zar0Akiko Morishita1Fumio Hashimoto2Kozue Sakao3Makoto Fujii4Koji Wada5De-Xing Hou6United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, JapanFaculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, JapanUnited Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan; Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, JapanFaculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, JapanTotsukawa Farm Co., Nejime Yokobeppu 487-1, Kagoshima Prefecture 893-2503, JapanUnited Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan; Faculty of Agriculture, University of The Ryukyus, Senbaru, Nishihara 1, Okinawa 903-0213, JapanUnited Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan; Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan; Corresponding author at: United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan. Tel./fax: +81 99 285 8649.Loquat (Eriobotrya japonica) leaves have been used as traditional medicine for chemoprevention and treatment of chronic inflammatory diseases although the evidence supporting their functions is still poor. This study aims to clarify the anti-inflammatory effects and molecular mechanisms of loquat tea extract (LTE), in both cell and animal models. LTE, especially C fraction, inhibited the production of pro-inflammatory factors including inducible nitric oxide synthase (iNOS), nitric oxide (NO), IL-6, RANTES and TNF-α. Cellular signaling data revealed that the downregulation of TGF-β-activated kinase (TAK1)-mediated both mitogen-activated protein kinase (MAPK) and NF-κB pathways were involved in the inhibition of pro-inflammatory factors by C fraction. Mouse paws edema model further confirmed the in vivo anti-inflammatory effects of LTE.http://www.sciencedirect.com/science/article/pii/S1756464613002879Loquat tea extractAnti-inflammatory effectPro-inflammatory factorCellular signalingMouse paw edema |
| spellingShingle | Phyu Phyu Khine Zar Akiko Morishita Fumio Hashimoto Kozue Sakao Makoto Fujii Koji Wada De-Xing Hou Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea Journal of Functional Foods Loquat tea extract Anti-inflammatory effect Pro-inflammatory factor Cellular signaling Mouse paw edema |
| title | Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea |
| title_full | Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea |
| title_fullStr | Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea |
| title_full_unstemmed | Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea |
| title_short | Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea |
| title_sort | anti inflammatory effects and molecular mechanisms of loquat eriobotrya japonica tea |
| topic | Loquat tea extract Anti-inflammatory effect Pro-inflammatory factor Cellular signaling Mouse paw edema |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613002879 |
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