Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus
Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909023000047 |
| _version_ | 1797801008145891328 |
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| author | Jan Damoiseaux Joyce van Beers |
| author_facet | Jan Damoiseaux Joyce van Beers |
| author_sort | Jan Damoiseaux |
| collection | DOAJ |
| description | Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes. |
| first_indexed | 2024-03-13T04:43:53Z |
| format | Article |
| id | doaj.art-df286676c00e47699fcab634f402b5af |
| institution | Directory Open Access Journal |
| issn | 2589-9090 |
| language | English |
| last_indexed | 2024-03-13T04:43:53Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj.art-df286676c00e47699fcab634f402b5af2023-06-19T04:29:16ZengElsevierJournal of Translational Autoimmunity2589-90902023-01-016100191Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosusJan Damoiseaux0Joyce van Beers1Corresponding author. Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229HX, Maastricht, the Netherlands.; Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the NetherlandsCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the NetherlandsAutoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes.http://www.sciencedirect.com/science/article/pii/S2589909023000047Systemic lupus erythematosusanti-dsDNABiomarkerLupus nephritis |
| spellingShingle | Jan Damoiseaux Joyce van Beers Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus Journal of Translational Autoimmunity Systemic lupus erythematosus anti-dsDNA Biomarker Lupus nephritis |
| title | Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus |
| title_full | Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus |
| title_fullStr | Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus |
| title_full_unstemmed | Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus |
| title_short | Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus |
| title_sort | autoantibodies to dsdna in the diagnosis classification and follow up of patients with systemic lupus erythematosus |
| topic | Systemic lupus erythematosus anti-dsDNA Biomarker Lupus nephritis |
| url | http://www.sciencedirect.com/science/article/pii/S2589909023000047 |
| work_keys_str_mv | AT jandamoiseaux autoantibodiestodsdnainthediagnosisclassificationandfollowupofpatientswithsystemiclupuserythematosus AT joycevanbeers autoantibodiestodsdnainthediagnosisclassificationandfollowupofpatientswithsystemiclupuserythematosus |