Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects
Amino acids are one of the most necessary substances in intracellular metabolic processes.aromatic aminoacids such as phenylalanine and tyrosine are precursor of melanin so are important materials for the skin pigmentation.metabolic disorders in the melanin synthesis causes milky macules on the skin...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2002-09-01
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| Series: | Journal of Kerman University of Medical Sciences |
| Subjects: | |
| Online Access: | https://jkmu.kmu.ac.ir/article_33820_098a9b642770013c2397508922777ec7.pdf |
| _version_ | 1797790651820015616 |
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| author | A GHolanhosinian H Hashem zehi S SHamsodini |
| author_facet | A GHolanhosinian H Hashem zehi S SHamsodini |
| author_sort | A GHolanhosinian |
| collection | DOAJ |
| description | Amino acids are one of the most necessary substances in intracellular metabolic processes.aromatic aminoacids such as phenylalanine and tyrosine are precursor of melanin so are important materials for the skin pigmentation.metabolic disorders in the melanin synthesis causes milky macules on the skin of patients,known as vitiligo.these patients are hypersensitive to sunlight and consequently at a higher risk for skin malignancies.because of negative psychological effects most patients (especially women)try to hide their disease.moreover long term treatment causes patients hoprlessness.in this study carried out on 50 vitiligo patients and 50 control cases,matched for sex and age the amount of phenylalanine and tyrosine in the fasting urine were determined by thin layer chromatography (TLC) method.results showed a significant difference (p<0.05) between the amount of phenylalanine in the urine of case group(8.15+_3.72 mg/dl) and control group (6.35+_3.94mg/dl).the amount of tyrosine in the urine of case group (9.56+_50.5 mg/dl) was less than that in the control group (11.32+_6.17mg/dl) and comparison of two groups in this regard showed a significant differnce only in the male subjects(p<0.01).ratio of phenylalanine and tyrosine to creatinine in urine was not significantly different in he two groups. |
| first_indexed | 2024-03-13T02:07:36Z |
| format | Article |
| id | doaj.art-df289eb87d334fd98684f5259841a06a |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:07:36Z |
| publishDate | 2002-09-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-df289eb87d334fd98684f5259841a06a2023-07-01T05:42:04ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432002-09-019421522133820Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjectsA GHolanhosinian0H Hashem zehiS SHamsodini1Associate professorprofessorAmino acids are one of the most necessary substances in intracellular metabolic processes.aromatic aminoacids such as phenylalanine and tyrosine are precursor of melanin so are important materials for the skin pigmentation.metabolic disorders in the melanin synthesis causes milky macules on the skin of patients,known as vitiligo.these patients are hypersensitive to sunlight and consequently at a higher risk for skin malignancies.because of negative psychological effects most patients (especially women)try to hide their disease.moreover long term treatment causes patients hoprlessness.in this study carried out on 50 vitiligo patients and 50 control cases,matched for sex and age the amount of phenylalanine and tyrosine in the fasting urine were determined by thin layer chromatography (TLC) method.results showed a significant difference (p<0.05) between the amount of phenylalanine in the urine of case group(8.15+_3.72 mg/dl) and control group (6.35+_3.94mg/dl).the amount of tyrosine in the urine of case group (9.56+_50.5 mg/dl) was less than that in the control group (11.32+_6.17mg/dl) and comparison of two groups in this regard showed a significant differnce only in the male subjects(p<0.01).ratio of phenylalanine and tyrosine to creatinine in urine was not significantly different in he two groups.https://jkmu.kmu.ac.ir/article_33820_098a9b642770013c2397508922777ec7.pdfphenylalanietyrosineurine aminoacidsvitiligo |
| spellingShingle | A GHolanhosinian H Hashem zehi S SHamsodini Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects Journal of Kerman University of Medical Sciences phenylalanie tyrosine urine aminoacids vitiligo |
| title | Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| title_full | Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| title_fullStr | Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| title_full_unstemmed | Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| title_short | Comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| title_sort | comparison of phenylalanine and tyrosine in urine of patients with vitiligo and normal subjects |
| topic | phenylalanie tyrosine urine aminoacids vitiligo |
| url | https://jkmu.kmu.ac.ir/article_33820_098a9b642770013c2397508922777ec7.pdf |
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