Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling
ABSTRACTPharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging. However, the identity of the specific cellular...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Autophagy Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2023.2277585 |
| _version_ | 1797629613003767808 |
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| author | Pierre-Louis Tharaux Olivia Lenoir |
| author_facet | Pierre-Louis Tharaux Olivia Lenoir |
| author_sort | Pierre-Louis Tharaux |
| collection | DOAJ |
| description | ABSTRACTPharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging. However, the identity of the specific cellular processes that autophagy controls in endothelial cells remained unclear. In this punctum, we discuss our recent findings on the multiple functions of autophagy in the endothelium. Particularly, we highlighted that autophagy controls flow-mediated vascular reactivity and remodeling. We have also focused on the role of autophagy machinery in regulating protein distribution within the cell and on the results demonstrating how autophagy modulates the cellular response to the microenvironment changes.Abbreviations: CXCL12: C-X-C motif chemokine ligand 12 EDN1: Endothelin 1 eNOS: endothelial Nitric Oxide Synthase FGF: Fibroblast Growth Factor NO: Nitric oxide VEGF: Vascular Endothelial Growth Factor VEGFR2: Vascular Endothelial Growth Factor Receptor 2 |
| first_indexed | 2024-03-11T10:55:37Z |
| format | Article |
| id | doaj.art-df2aa9fbb9534bf89e808ad5fd46e46a |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-11T10:55:37Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-df2aa9fbb9534bf89e808ad5fd46e46a2023-11-13T09:56:58ZengTaylor & Francis GroupAutophagy Reports2769-41272023-12-012110.1080/27694127.2023.2277585Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signallingPierre-Louis Tharaux0Olivia Lenoir1Université Paris Cité, Inserm, Paris Cardiovascular Center (PARCC) – 75015 Paris, FranceUniversité Paris Cité, Inserm, Paris Cardiovascular Center (PARCC) – 75015 Paris, FranceABSTRACTPharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging. However, the identity of the specific cellular processes that autophagy controls in endothelial cells remained unclear. In this punctum, we discuss our recent findings on the multiple functions of autophagy in the endothelium. Particularly, we highlighted that autophagy controls flow-mediated vascular reactivity and remodeling. We have also focused on the role of autophagy machinery in regulating protein distribution within the cell and on the results demonstrating how autophagy modulates the cellular response to the microenvironment changes.Abbreviations: CXCL12: C-X-C motif chemokine ligand 12 EDN1: Endothelin 1 eNOS: endothelial Nitric Oxide Synthase FGF: Fibroblast Growth Factor NO: Nitric oxide VEGF: Vascular Endothelial Growth Factor VEGFR2: Vascular Endothelial Growth Factor Receptor 2https://www.tandfonline.com/doi/10.1080/27694127.2023.2277585Autophagyendotheliumflow-mediated vasodilationVEGFR2mitochondrial dysfunction |
| spellingShingle | Pierre-Louis Tharaux Olivia Lenoir Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling Autophagy Reports Autophagy endothelium flow-mediated vasodilation VEGFR2 mitochondrial dysfunction |
| title | Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling |
| title_full | Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling |
| title_fullStr | Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling |
| title_full_unstemmed | Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling |
| title_short | Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling |
| title_sort | autophagy in the endothelium commands flow mediated vascular reactivity and remodelling and regulates vegfr2 subcellular localization and signalling |
| topic | Autophagy endothelium flow-mediated vasodilation VEGFR2 mitochondrial dysfunction |
| url | https://www.tandfonline.com/doi/10.1080/27694127.2023.2277585 |
| work_keys_str_mv | AT pierrelouistharaux autophagyintheendotheliumcommandsflowmediatedvascularreactivityandremodellingandregulatesvegfr2subcellularlocalizationandsignalling AT olivialenoir autophagyintheendotheliumcommandsflowmediatedvascularreactivityandremodellingandregulatesvegfr2subcellularlocalizationandsignalling |