Cell Migration Research Based on Organ-on-Chip-Related Approaches
Microfluidic devices have been widely used for cell migration research over the last two decades, owing to their attractive features in cellular microenvironment control and quantitative single-cell migration analysis. However, the majority of the microfluidic cell migration studies have focused on...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/8/11/324 |
| _version_ | 1818577308142796800 |
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| author | Xiaoou Ren David Levin Francis Lin |
| author_facet | Xiaoou Ren David Levin Francis Lin |
| author_sort | Xiaoou Ren |
| collection | DOAJ |
| description | Microfluidic devices have been widely used for cell migration research over the last two decades, owing to their attractive features in cellular microenvironment control and quantitative single-cell migration analysis. However, the majority of the microfluidic cell migration studies have focused on single cell types and have configured microenvironments that are greatly simplified compared with the in-vivo conditions they aspire to model. In addition, although cell migration is considered an important target for disease diagnosis and therapeutics, very few microfluidic cell migration studies involved clinical samples from patients. Therefore, more sophisticated microfluidic systems are required to model the complex in-vivo microenvironment at the tissue or organ level for cell migration studies and to explore cell migration-related clinical applications. Research in this direction that employs organ-on-chip-related approaches for cell migration analysis has been increasingly reported in recent years. In this paper, we briefly introduce the general background of cell migration and organ-on-chip research, followed by a detailed review of specific cell migration studies using organ-on-chip-related approaches, and conclude by discussing our perspectives of the challenges, opportunities and future directions. |
| first_indexed | 2024-12-16T06:27:51Z |
| format | Article |
| id | doaj.art-df2ac8e7521b42e59f441d0e7191dbdd |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-16T06:27:51Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-df2ac8e7521b42e59f441d0e7191dbdd2022-12-21T22:40:57ZengMDPI AGMicromachines2072-666X2017-10-0181132410.3390/mi8110324mi8110324Cell Migration Research Based on Organ-on-Chip-Related ApproachesXiaoou Ren0David Levin1Francis Lin2Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaDepartment of Biosystems Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaDepartment of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaMicrofluidic devices have been widely used for cell migration research over the last two decades, owing to their attractive features in cellular microenvironment control and quantitative single-cell migration analysis. However, the majority of the microfluidic cell migration studies have focused on single cell types and have configured microenvironments that are greatly simplified compared with the in-vivo conditions they aspire to model. In addition, although cell migration is considered an important target for disease diagnosis and therapeutics, very few microfluidic cell migration studies involved clinical samples from patients. Therefore, more sophisticated microfluidic systems are required to model the complex in-vivo microenvironment at the tissue or organ level for cell migration studies and to explore cell migration-related clinical applications. Research in this direction that employs organ-on-chip-related approaches for cell migration analysis has been increasingly reported in recent years. In this paper, we briefly introduce the general background of cell migration and organ-on-chip research, followed by a detailed review of specific cell migration studies using organ-on-chip-related approaches, and conclude by discussing our perspectives of the challenges, opportunities and future directions.https://www.mdpi.com/2072-666X/8/11/324microfluidic devicecell migrationorgan-on-chip |
| spellingShingle | Xiaoou Ren David Levin Francis Lin Cell Migration Research Based on Organ-on-Chip-Related Approaches Micromachines microfluidic device cell migration organ-on-chip |
| title | Cell Migration Research Based on Organ-on-Chip-Related Approaches |
| title_full | Cell Migration Research Based on Organ-on-Chip-Related Approaches |
| title_fullStr | Cell Migration Research Based on Organ-on-Chip-Related Approaches |
| title_full_unstemmed | Cell Migration Research Based on Organ-on-Chip-Related Approaches |
| title_short | Cell Migration Research Based on Organ-on-Chip-Related Approaches |
| title_sort | cell migration research based on organ on chip related approaches |
| topic | microfluidic device cell migration organ-on-chip |
| url | https://www.mdpi.com/2072-666X/8/11/324 |
| work_keys_str_mv | AT xiaoouren cellmigrationresearchbasedonorganonchiprelatedapproaches AT davidlevin cellmigrationresearchbasedonorganonchiprelatedapproaches AT francislin cellmigrationresearchbasedonorganonchiprelatedapproaches |