| Summary: | <i>Helicobacter pylori</i> is a Gram-negative bacterium responsible for the development of gastric diseases. The issue of spreading antibiotic resistance of <i>H. pylori</i> and its limited therapeutic options is an important topic in modern gastroenterology. This phenomenon is greatly associated with a very narrow range of antibiotics used in standard therapies and, as a consequence, an alarmingly high detection of multidrug-resistant <i>H. pylori</i> strains. For this reason, scientists are increasingly focused on the search for new substances that will not only exhibit antibacterial effect against <i>H. pylori</i>, but also potentiate the activity of antibiotics. The aim of the current review is to present scientific reports showing newly discovered or repurposed compounds with an ability to enhance the antimicrobial activity of classically used antibiotics against <i>H. pylori</i>. To gain a broader context in their future application in therapies of <i>H. pylori</i> infections, their antimicrobial properties, such as minimal inhibitory concentrations and minimal bactericidal concentrations, dose- and time-dependent mode of action, and, if characterized, anti-biofilm and/or in vivo activity are further described. The authors of this review hope that this article will encourage the scientific community to expand research on the important issue of synergistic therapies in the context of combating <i>H. pylori</i> infections.
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