Preparation and Properties of Bimetallic Chitosan Spherical Microgels
The aim of this work was to prepare bimetallic chitosan microgels with high sphericity and investigate the influences of metal-ion type and content on the size, morphology, swelling, degradation and biological properties of microgels. Amino and hydroxyl groups of chitosan (deacetylation degree, <...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/6/1480 |
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| author | Andrea Lončarević Karla Ostojić Inga Urlić Anamarija Rogina |
| author_facet | Andrea Lončarević Karla Ostojić Inga Urlić Anamarija Rogina |
| author_sort | Andrea Lončarević |
| collection | DOAJ |
| description | The aim of this work was to prepare bimetallic chitosan microgels with high sphericity and investigate the influences of metal-ion type and content on the size, morphology, swelling, degradation and biological properties of microgels. Amino and hydroxyl groups of chitosan (deacetylation degree, <i>DD</i>, of 83.2% and 96.9%) served as ligands in the Cu<sup>2+</sup>–Zn<sup>2+</sup>/chitosan complexes with various contents of cupric and zinc ions. The electrohydrodynamic atomization process was used to produce highly spherical microgels with a narrow size distribution and with surface morphology changing from wrinkled to smooth by increasing Cu<sup>2+</sup> ions’ quantity in bimetallic systems for both used chitosans. The size of the bimetallic chitosan particles was estimated to be between 60 and 110 µm for both used chitosans, and FTIR spectroscopy indicated the formation of complexes through physical interactions between the chitosans’ functional groups and metal ions. The swelling capacity of bimetallic chitosan particles decreases as the <i>DD</i> and copper (II) ion content increase as a result of stronger complexation with respect to zinc (II) ions. Bimetallic chitosan microgels showed good stability during four weeks of enzymatic degradation, and bimetallic systems with smaller amounts of Cu<sup>2+</sup> ions showed good cytocompatibility for both used chitosans. |
| first_indexed | 2024-03-11T05:59:40Z |
| format | Article |
| id | doaj.art-df2b0903e7c44750ac91269af708d71f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T05:59:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-df2b0903e7c44750ac91269af708d71f2023-11-17T13:26:10ZengMDPI AGPolymers2073-43602023-03-01156148010.3390/polym15061480Preparation and Properties of Bimetallic Chitosan Spherical MicrogelsAndrea Lončarević0Karla Ostojić1Inga Urlić2Anamarija Rogina3Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10000 Zagreb, CroatiaFaculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, CroatiaFaculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, CroatiaFaculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10000 Zagreb, CroatiaThe aim of this work was to prepare bimetallic chitosan microgels with high sphericity and investigate the influences of metal-ion type and content on the size, morphology, swelling, degradation and biological properties of microgels. Amino and hydroxyl groups of chitosan (deacetylation degree, <i>DD</i>, of 83.2% and 96.9%) served as ligands in the Cu<sup>2+</sup>–Zn<sup>2+</sup>/chitosan complexes with various contents of cupric and zinc ions. The electrohydrodynamic atomization process was used to produce highly spherical microgels with a narrow size distribution and with surface morphology changing from wrinkled to smooth by increasing Cu<sup>2+</sup> ions’ quantity in bimetallic systems for both used chitosans. The size of the bimetallic chitosan particles was estimated to be between 60 and 110 µm for both used chitosans, and FTIR spectroscopy indicated the formation of complexes through physical interactions between the chitosans’ functional groups and metal ions. The swelling capacity of bimetallic chitosan particles decreases as the <i>DD</i> and copper (II) ion content increase as a result of stronger complexation with respect to zinc (II) ions. Bimetallic chitosan microgels showed good stability during four weeks of enzymatic degradation, and bimetallic systems with smaller amounts of Cu<sup>2+</sup> ions showed good cytocompatibility for both used chitosans.https://www.mdpi.com/2073-4360/15/6/1480bimetallic microgelelectrosprayingcopperzincchitosancytotoxicity |
| spellingShingle | Andrea Lončarević Karla Ostojić Inga Urlić Anamarija Rogina Preparation and Properties of Bimetallic Chitosan Spherical Microgels Polymers bimetallic microgel electrospraying copper zinc chitosan cytotoxicity |
| title | Preparation and Properties of Bimetallic Chitosan Spherical Microgels |
| title_full | Preparation and Properties of Bimetallic Chitosan Spherical Microgels |
| title_fullStr | Preparation and Properties of Bimetallic Chitosan Spherical Microgels |
| title_full_unstemmed | Preparation and Properties of Bimetallic Chitosan Spherical Microgels |
| title_short | Preparation and Properties of Bimetallic Chitosan Spherical Microgels |
| title_sort | preparation and properties of bimetallic chitosan spherical microgels |
| topic | bimetallic microgel electrospraying copper zinc chitosan cytotoxicity |
| url | https://www.mdpi.com/2073-4360/15/6/1480 |
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