The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents
Introduction: An adverse pattern of blood lipids and cardiovascular abnormalities starts in obese children during childhood and neopterin serves as a marker for cardiovascular disease. Unfortunately, the data for children and adolescents, particularly, in the Indian population, are scarce. The p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2866/3-%205128_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP).pdf |
| Summary: | Introduction: An adverse pattern of blood lipids and cardiovascular
abnormalities starts in obese children during childhood and
neopterin serves as a marker for cardiovascular disease.
Unfortunately, the data for children and adolescents, particularly,
in the Indian population, are scarce. The present study aimed at
evaluating the levels of serum neopterin in obese and overweight
children and adolescents of the Indian population.
Methods: The study groups included 296 school going children
and adolescents. (96 obese and 97 overweight subjects were
compared with 103 normal controls who were aged between 10-
17 years). The anthropometric variables, the lipid profile, the fasting
serum glucose which was analyzed by using an autoanalyzer and
the serum neopterin levels were assayed by HPLC (Shimazdu) by
using the method of Palfrey et al., 1993. The serum insulin levels
were measured by using ELISA kits.
Results: The serum neopterin levels (nmol/l) were elevated
significantly in the obese (7.4±1.4) and overweight (6.4±0.8)
(p<0.001) children and adolescents than in the controls (4.9±0.9).
The serum neopterin levels showed a positive correlation with
the BMI (r=0.79), WHR (r=0.5), systolic (r=0.44) and diastolic
blood pressures (r= 0.25), insulin (r=0.57), HOMAIR (r=0.55), total
cholesterol (r=0.35), triglycerides (r=0.20) and LDL-C (r=0.27) and
they showed a negative correlation with HDL-C (r=-0.15) and
fasting glucose (r= -0.3).
Conclusion: This study revealed a good relationship between serum
neopterin and the anthropometric and biochemical parameters. We,
therefore, aim to conduct regular camps at schools to counsel and
advise the identified overweight and obese children to go for physical
exercise and a balanced diet. The implementation of preventive
measures from early childhood will have far reaching benefits, as even
the prevalence of other obesity related disorders could decline. |
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| ISSN: | 2249-782X 0973-709X |