The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents
Introduction: An adverse pattern of blood lipids and cardiovascular abnormalities starts in obese children during childhood and neopterin serves as a marker for cardiovascular disease. Unfortunately, the data for children and adolescents, particularly, in the Indian population, are scarce. The p...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2013-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/2866/3-%205128_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP).pdf |
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| author | Srinivasa Nageswara Rao G. Prema Gurumurthy Sruti E. K.M. Cherian |
| author_facet | Srinivasa Nageswara Rao G. Prema Gurumurthy Sruti E. K.M. Cherian |
| author_sort | Srinivasa Nageswara Rao G. |
| collection | DOAJ |
| description | Introduction: An adverse pattern of blood lipids and cardiovascular
abnormalities starts in obese children during childhood and
neopterin serves as a marker for cardiovascular disease.
Unfortunately, the data for children and adolescents, particularly,
in the Indian population, are scarce. The present study aimed at
evaluating the levels of serum neopterin in obese and overweight
children and adolescents of the Indian population.
Methods: The study groups included 296 school going children
and adolescents. (96 obese and 97 overweight subjects were
compared with 103 normal controls who were aged between 10-
17 years). The anthropometric variables, the lipid profile, the fasting
serum glucose which was analyzed by using an autoanalyzer and
the serum neopterin levels were assayed by HPLC (Shimazdu) by
using the method of Palfrey et al., 1993. The serum insulin levels
were measured by using ELISA kits.
Results: The serum neopterin levels (nmol/l) were elevated
significantly in the obese (7.4±1.4) and overweight (6.4±0.8)
(p<0.001) children and adolescents than in the controls (4.9±0.9).
The serum neopterin levels showed a positive correlation with
the BMI (r=0.79), WHR (r=0.5), systolic (r=0.44) and diastolic
blood pressures (r= 0.25), insulin (r=0.57), HOMAIR (r=0.55), total
cholesterol (r=0.35), triglycerides (r=0.20) and LDL-C (r=0.27) and
they showed a negative correlation with HDL-C (r=-0.15) and
fasting glucose (r= -0.3).
Conclusion: This study revealed a good relationship between serum
neopterin and the anthropometric and biochemical parameters. We,
therefore, aim to conduct regular camps at schools to counsel and
advise the identified overweight and obese children to go for physical
exercise and a balanced diet. The implementation of preventive
measures from early childhood will have far reaching benefits, as even
the prevalence of other obesity related disorders could decline. |
| first_indexed | 2024-12-23T10:41:37Z |
| format | Article |
| id | doaj.art-df2c7fbf09c54311addfcbd80ab1a69b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-23T10:41:37Z |
| publishDate | 2013-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-df2c7fbf09c54311addfcbd80ab1a69b2022-12-21T17:50:09ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-04-017461862110.7860/JCDR/2013/5128.2866The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and AdolescentsSrinivasa Nageswara Rao G.0Prema Gurumurthy1Sruti E.2K.M. Cherian3Assistant Professor, Department of Biochemistry, Tagore Medical College & Hospital, Rathinamangalam, Melakkottaiyur Post, Chennai-600 127. India.Director – Research, Training & Applications, International Centre for Cardio-Thoracic and Vascular Diseases, Chennai, India.Tutor, Department of Biochemistry, Tagore Medical College & Hospital, Rathinamangalam, Melakkottaiyur Post, Chennai-600 127, India.Chairman and CEO, International Centre for Cardio-Thoracic and Vascular Diseases, Chennai, India.Introduction: An adverse pattern of blood lipids and cardiovascular abnormalities starts in obese children during childhood and neopterin serves as a marker for cardiovascular disease. Unfortunately, the data for children and adolescents, particularly, in the Indian population, are scarce. The present study aimed at evaluating the levels of serum neopterin in obese and overweight children and adolescents of the Indian population. Methods: The study groups included 296 school going children and adolescents. (96 obese and 97 overweight subjects were compared with 103 normal controls who were aged between 10- 17 years). The anthropometric variables, the lipid profile, the fasting serum glucose which was analyzed by using an autoanalyzer and the serum neopterin levels were assayed by HPLC (Shimazdu) by using the method of Palfrey et al., 1993. The serum insulin levels were measured by using ELISA kits. Results: The serum neopterin levels (nmol/l) were elevated significantly in the obese (7.4±1.4) and overweight (6.4±0.8) (p<0.001) children and adolescents than in the controls (4.9±0.9). The serum neopterin levels showed a positive correlation with the BMI (r=0.79), WHR (r=0.5), systolic (r=0.44) and diastolic blood pressures (r= 0.25), insulin (r=0.57), HOMAIR (r=0.55), total cholesterol (r=0.35), triglycerides (r=0.20) and LDL-C (r=0.27) and they showed a negative correlation with HDL-C (r=-0.15) and fasting glucose (r= -0.3). Conclusion: This study revealed a good relationship between serum neopterin and the anthropometric and biochemical parameters. We, therefore, aim to conduct regular camps at schools to counsel and advise the identified overweight and obese children to go for physical exercise and a balanced diet. The implementation of preventive measures from early childhood will have far reaching benefits, as even the prevalence of other obesity related disorders could decline.https://jcdr.net/articles/PDF/2866/3-%205128_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP).pdfchildrenobesityneopterinhplc |
| spellingShingle | Srinivasa Nageswara Rao G. Prema Gurumurthy Sruti E. K.M. Cherian The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents Journal of Clinical and Diagnostic Research children obesity neopterin hplc |
| title | The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents |
| title_full | The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents |
| title_fullStr | The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents |
| title_full_unstemmed | The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents |
| title_short | The Clinical and Biochemical Parameters in Relation to the Serum Neopterin Levels in Indian Children and Adolescents |
| title_sort | clinical and biochemical parameters in relation to the serum neopterin levels in indian children and adolescents |
| topic | children obesity neopterin hplc |
| url | https://jcdr.net/articles/PDF/2866/3-%205128_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP).pdf |
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