Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin
In this study, a novel promising approach for the fabrication of Halloysite nanotube (HNT) nanocomposites, based on the amino acid named Methionine (Met), was investigated. For this purpose, Met layered on the outer silane functionalized surface of HNT for controlled release of Phenytoin sodium (PHT...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/15/2576 |
| _version_ | 1797525215424544768 |
|---|---|
| author | Majid Abdouss Nastaran Radgoudarzi Alireza Mohebali Elaheh Kowsari Mojtaba Koosha Tianduo Li |
| author_facet | Majid Abdouss Nastaran Radgoudarzi Alireza Mohebali Elaheh Kowsari Mojtaba Koosha Tianduo Li |
| author_sort | Majid Abdouss |
| collection | DOAJ |
| description | In this study, a novel promising approach for the fabrication of Halloysite nanotube (HNT) nanocomposites, based on the amino acid named Methionine (Met), was investigated. For this purpose, Met layered on the outer silane functionalized surface of HNT for controlled release of Phenytoin sodium (PHT). The resulting nanocomposite (MNT-g-Met) was characterized by FTIR, XRD, Zeta potential, TGA, TEM and FE-SEM. The FT-IR results showed APTES and Met peaks, which proved the modification of the HNTs. The zeta-potential results showed the interaction between APTES (+53.30) and Met (+38.80) on the HNTs (−30.92). The FE-SEM micrographs have displayed the grafting of Met on the modified HNTs due to the nanotube conversion to a rough and indistinguishable form. The amount of encapsulation efficiency (EE) and loading efficiency (LE) of MNT-g-Met was 74.48% and 37.24%, while pure HNT was 57.5%, and 28.75%, respectively. In-vitro studies showed that HNT had a burst release (70% in 6 h) in phosphate buffer while MNT-g-Met has more controlled release profile (30.05 in 6 h) and it was found to be fitted with the Korsmeyer-Peppas model. Due to the loading efficiency and controlled release profile, the nanocomposite promote a good potential for drug delivery of PHT. |
| first_indexed | 2024-03-10T09:10:36Z |
| format | Article |
| id | doaj.art-df2c8e2001254236a48fafa6025202de |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T09:10:36Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-df2c8e2001254236a48fafa6025202de2023-11-22T06:05:00ZengMDPI AGPolymers2073-43602021-08-011315257610.3390/polym13152576Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of PhenytoinMajid Abdouss0Nastaran Radgoudarzi1Alireza Mohebali2Elaheh Kowsari3Mojtaba Koosha4Tianduo Li5Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaPharmaceutical Sciences Research Center, Department of Chemistry, Amirkabir University of Technology, No. 350, Hafez Ave, Valiasr Square, Tehran 1591634311, IranPharmaceutical Sciences Research Center, Department of Chemistry, Amirkabir University of Technology, No. 350, Hafez Ave, Valiasr Square, Tehran 1591634311, IranPharmaceutical Sciences Research Center, Department of Chemistry, Amirkabir University of Technology, No. 350, Hafez Ave, Valiasr Square, Tehran 1591634311, IranShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaShandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaIn this study, a novel promising approach for the fabrication of Halloysite nanotube (HNT) nanocomposites, based on the amino acid named Methionine (Met), was investigated. For this purpose, Met layered on the outer silane functionalized surface of HNT for controlled release of Phenytoin sodium (PHT). The resulting nanocomposite (MNT-g-Met) was characterized by FTIR, XRD, Zeta potential, TGA, TEM and FE-SEM. The FT-IR results showed APTES and Met peaks, which proved the modification of the HNTs. The zeta-potential results showed the interaction between APTES (+53.30) and Met (+38.80) on the HNTs (−30.92). The FE-SEM micrographs have displayed the grafting of Met on the modified HNTs due to the nanotube conversion to a rough and indistinguishable form. The amount of encapsulation efficiency (EE) and loading efficiency (LE) of MNT-g-Met was 74.48% and 37.24%, while pure HNT was 57.5%, and 28.75%, respectively. In-vitro studies showed that HNT had a burst release (70% in 6 h) in phosphate buffer while MNT-g-Met has more controlled release profile (30.05 in 6 h) and it was found to be fitted with the Korsmeyer-Peppas model. Due to the loading efficiency and controlled release profile, the nanocomposite promote a good potential for drug delivery of PHT.https://www.mdpi.com/2073-4360/13/15/2576HNTwound healingphenytoinbio-nanocomposite |
| spellingShingle | Majid Abdouss Nastaran Radgoudarzi Alireza Mohebali Elaheh Kowsari Mojtaba Koosha Tianduo Li Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin Polymers HNT wound healing phenytoin bio-nanocomposite |
| title | Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin |
| title_full | Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin |
| title_fullStr | Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin |
| title_full_unstemmed | Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin |
| title_short | Fabrication of Bio-Nanocomposite Based on HNT-Methionine for Controlled Release of Phenytoin |
| title_sort | fabrication of bio nanocomposite based on hnt methionine for controlled release of phenytoin |
| topic | HNT wound healing phenytoin bio-nanocomposite |
| url | https://www.mdpi.com/2073-4360/13/15/2576 |
| work_keys_str_mv | AT majidabdouss fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin AT nastaranradgoudarzi fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin AT alirezamohebali fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin AT elahehkowsari fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin AT mojtabakoosha fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin AT tianduoli fabricationofbionanocompositebasedonhntmethionineforcontrolledreleaseofphenytoin |