Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma

Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma

Introduction Despite the advent of immunotherapy as a promising therapeutic, glioblastoma (GBM) remains resistant to using checkpoint blockade due to its highly immunosuppressive tumor milieu. Moreover, current anti-PD-1 treatment requires multiple infusions with adverse systemic effects. Therefore,...

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Bibliographic Details
Main Authors: John Choi, Ayush Pant, Ravi Medikonda, Young-Hoon Kim, Denis Routkevitch, Laura Saleh, Luqing Tong, Hok Yee Chan, Jessie Nedrow, Christopher Jackson, Christina Jackson, Michael Lim
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
immunotherapy
glioblastoma
lymph node
local delivery
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1940673

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