Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveol...
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| Format: | Article |
| Language: | English |
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Sciendo
2014-12-01
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| Series: | Acta Veterinaria |
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| Online Access: | https://doi.org/10.2478/acve-2014-0045 |
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| author | Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević |
| author_facet | Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević |
| author_sort | Zoran Lazić |
| collection | DOAJ |
| description | The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the fl ap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the infl uence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one. |
| first_indexed | 2024-12-19T03:16:15Z |
| format | Article |
| id | doaj.art-df2e30fd4f104759b85820913ef2f618 |
| institution | Directory Open Access Journal |
| issn | 1820-7448 |
| language | English |
| last_indexed | 2024-12-19T03:16:15Z |
| publishDate | 2014-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Veterinaria |
| spelling | doaj.art-df2e30fd4f104759b85820913ef2f6182022-12-21T20:37:53ZengSciendoActa Veterinaria1820-74482014-12-0164447749210.2478/acve-2014-0045Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine OriginZoran Lazić0Marija Bubalo1Radomir Milović2Stevo Matijević3Marko Magić4Igor Đorđević5Clinic for Dentistry Military Medical Academy, Belgrade, SerbiaClinic for Dentistry Military Medical Academy, Belgrade, SerbiaClinic for Dentistry Military Medical Academy, Belgrade, SerbiaClinic for Dentistry Military Medical Academy, Belgrade, SerbiaClinic for Dentistry Military Medical Academy, Belgrade, SerbiaFaculty of Dentistry, Belgrade, SerbiaThe properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the fl ap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the infl uence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one.https://doi.org/10.2478/acve-2014-0045bovine resorbable membranedog mandible defectguided bone regenerationhuman resorbable membranemembrane thickness |
| spellingShingle | Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin Acta Veterinaria bovine resorbable membrane dog mandible defect guided bone regeneration human resorbable membrane membrane thickness |
| title | Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin |
| title_full | Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin |
| title_fullStr | Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin |
| title_full_unstemmed | Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin |
| title_short | Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin |
| title_sort | comparison of resorbable membranes for guided bone regeneration of human and bovine origin |
| topic | bovine resorbable membrane dog mandible defect guided bone regeneration human resorbable membrane membrane thickness |
| url | https://doi.org/10.2478/acve-2014-0045 |
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