Impact of local anesthetics on epigenetics in cancer

Impact of local anesthetics on epigenetics in cancer

Defective silencing of tumor suppressor genes through epigenetic alterations contributes to oncogenesis by perturbing cell cycle regulation, DNA repair or cell death mechanisms. Reversal of such epigenetic changes including DNA hypermethylation provides a promising anticancer strategy. Until now, th...

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Bibliographic Details
Main Authors: Lucillia Bezu, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
local anesthetics
epigenetic
cancer
demethylation
miRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.849895/full

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