Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study
BackgroundTo explore the potential of synchrotron radiation (SR) phase contrast imaging (PCI) for real-time microbubble formation monitoring during radiofrequency ablation (RFA).MethodsRFA was performed on ex vivo porcine muscle tissue using unipolar and multi-tined expandable electrodes. Images of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01709/full |
| _version_ | 1818610046580293632 |
|---|---|
| author | Wei Huang Jian Lu Rongbiao Tang Zhiyuan Wu Qingbing Wang Xiaoyi Ding Zhongmin Wang Kemin Chen |
| author_facet | Wei Huang Jian Lu Rongbiao Tang Zhiyuan Wu Qingbing Wang Xiaoyi Ding Zhongmin Wang Kemin Chen |
| author_sort | Wei Huang |
| collection | DOAJ |
| description | BackgroundTo explore the potential of synchrotron radiation (SR) phase contrast imaging (PCI) for real-time microbubble formation monitoring during radiofrequency ablation (RFA).MethodsRFA was performed on ex vivo porcine muscle tissue using unipolar and multi-tined expandable electrodes. Images of microbubble formation in the samples were captured by both SR PCI and absorption contrast imaging. The synchronous ablation temperature was recorded. Each RFA electrode type group contained 6 samples. Ablation size was assessed by histologic examination.ResultsMicrobubble formation during RFA could be visualized by SR PCI. The diameter of the microbubbles revealed on the image ranged from tens of microns to several millimeters, and these microbubbles first appeared at the edge of the RFA electrode when the target region temperature reached approximately 60°C and rapidly extended outwards. The average microbubble range measured on PCI was 17.66 ± 0.74 mm. The average range of coagulation necrosis measured by histological examination was 17.22 ± 0.38 mm. There was no significant difference between them (P > 0.05). The range of microbubbles corresponded to the ablation zone.ConclusionPCI enabled real-time high-resolution visualization of microbubble formation during RFA, indicating a potential for its use in ablation monitoring. |
| first_indexed | 2024-12-16T15:08:12Z |
| format | Article |
| id | doaj.art-df2efd10360d4bae8a5b80ac88beb918 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T15:08:12Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-df2efd10360d4bae8a5b80ac88beb9182022-12-21T22:27:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01709522887Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo StudyWei Huang0Jian Lu1Rongbiao Tang2Zhiyuan Wu3Qingbing Wang4Xiaoyi Ding5Zhongmin Wang6Kemin Chen7Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital/Luwan Branch, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital/Luwan Branch, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaBackgroundTo explore the potential of synchrotron radiation (SR) phase contrast imaging (PCI) for real-time microbubble formation monitoring during radiofrequency ablation (RFA).MethodsRFA was performed on ex vivo porcine muscle tissue using unipolar and multi-tined expandable electrodes. Images of microbubble formation in the samples were captured by both SR PCI and absorption contrast imaging. The synchronous ablation temperature was recorded. Each RFA electrode type group contained 6 samples. Ablation size was assessed by histologic examination.ResultsMicrobubble formation during RFA could be visualized by SR PCI. The diameter of the microbubbles revealed on the image ranged from tens of microns to several millimeters, and these microbubbles first appeared at the edge of the RFA electrode when the target region temperature reached approximately 60°C and rapidly extended outwards. The average microbubble range measured on PCI was 17.66 ± 0.74 mm. The average range of coagulation necrosis measured by histological examination was 17.22 ± 0.38 mm. There was no significant difference between them (P > 0.05). The range of microbubbles corresponded to the ablation zone.ConclusionPCI enabled real-time high-resolution visualization of microbubble formation during RFA, indicating a potential for its use in ablation monitoring.https://www.frontiersin.org/article/10.3389/fonc.2020.01709/fullradiofrequency ablationsynchrotronmicrobubblesradiationphase contrast imaging |
| spellingShingle | Wei Huang Jian Lu Rongbiao Tang Zhiyuan Wu Qingbing Wang Xiaoyi Ding Zhongmin Wang Kemin Chen Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study Frontiers in Oncology radiofrequency ablation synchrotron microbubbles radiation phase contrast imaging |
| title | Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study |
| title_full | Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study |
| title_fullStr | Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study |
| title_full_unstemmed | Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study |
| title_short | Phase Contrast Imaging Based Microbubble Monitoring of Radiofrequency Ablation: An ex vivo Study |
| title_sort | phase contrast imaging based microbubble monitoring of radiofrequency ablation an ex vivo study |
| topic | radiofrequency ablation synchrotron microbubbles radiation phase contrast imaging |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01709/full |
| work_keys_str_mv | AT weihuang phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT jianlu phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT rongbiaotang phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT zhiyuanwu phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT qingbingwang phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT xiaoyiding phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT zhongminwang phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy AT keminchen phasecontrastimagingbasedmicrobubblemonitoringofradiofrequencyablationanexvivostudy |