Metallomics in pulmonary arterial hypertension patients
Abstract Pulmonary arterial hypertension (PAH) prevalence is increasing worldwide, and the prognosis is poor with 5‐year survival < 50% in high risk patients. The relationship between metal exposure/essential metal dyshomeostasis and PAH/right ventricular dysfunction is less investigated. The aim...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Pulmonary Circulation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pul2.12202 |
| _version_ | 1797824206255161344 |
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| author | Karim El‐Kersh C. Danielle Hopkins Xiaoyong Wu Shesh N. Rai Matthew C. Cave M. Ryan Smith Young‐Mi Go Dean P. Jones Lu Cai Jiapeng Huang |
| author_facet | Karim El‐Kersh C. Danielle Hopkins Xiaoyong Wu Shesh N. Rai Matthew C. Cave M. Ryan Smith Young‐Mi Go Dean P. Jones Lu Cai Jiapeng Huang |
| author_sort | Karim El‐Kersh |
| collection | DOAJ |
| description | Abstract Pulmonary arterial hypertension (PAH) prevalence is increasing worldwide, and the prognosis is poor with 5‐year survival < 50% in high risk patients. The relationship between metal exposure/essential metal dyshomeostasis and PAH/right ventricular dysfunction is less investigated. The aim of this study is to investigate vegetable consumptions and metal levels between PAH patients and controls. This was a prospective, single center pilot study. Questionnaires were completed by all study subjects (20 PAH patients and 10 healthy controls) on smoking, metal exposure risks, metal supplements, and vegetable consumptions. Blood and urine samples were collected to measure 25 metal levels in blood, plasma, and urine using an X Series II quadrupole inductively coupled plasma mass spectrometry. Statistical analysis was conducted using SAS 9.5 and results with p value < 0.05 were considered significant. Vegetables consumptions (broccoli risk ratio [RR] = 0.4, CI = (0.2, 0.9)], cabbage [RR = 0.2, CI = (0.1, 0.8)], and brussel sprouts [RR = 0.2, CI = (0.1, 0.5)]) are associated with less risks of PAH. In the plasma samples, silver (p < 0.001), and copper (p = 0.002) levels were significantly higher in PAH patients. There was significant positive correlation between cardiac output and cardiac index with plasma levels of silver (r = 0.665, p = 0.001 and r = 0.678 p = 0.001), respectively. There was significant correlation between mixed venous saturation, 6‐min walk distance, and last BNP with plasma levels of chromium (r = −0.520, p = 0.022; r = −0.55, p = 0.014; r = 0.463, p = 0.039), respectively. In conclusion, there are significant differences between PAH and control groups in terms of vegetable consumptions and metal concentrations. Silver and chromium levels are correlated with clinical indicators of PAH severities. |
| first_indexed | 2024-03-13T10:35:31Z |
| format | Article |
| id | doaj.art-df3155f66ad0499d916316284ac53666 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-03-13T10:35:31Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-df3155f66ad0499d916316284ac536662023-05-18T06:26:29ZengWileyPulmonary Circulation2045-89402023-01-01131n/an/a10.1002/pul2.12202Metallomics in pulmonary arterial hypertension patientsKarim El‐Kersh0C. Danielle Hopkins1Xiaoyong Wu2Shesh N. Rai3Matthew C. Cave4M. Ryan Smith5Young‐Mi Go6Dean P. Jones7Lu Cai8Jiapeng Huang9Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine University of Nebraska Medical Center Omaha Nebraska USADepartment of Anesthesiology and Perioperative Medicine University of Louisville School of Medicine Louisville Kentucky USADepartment of Environmental Health University of Cincinnati Cincinnati Ohio USADepartment of Environmental Health University of Cincinnati Cincinnati Ohio USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Louisville School of Medicine Louisville Kentucky USADivision of Pulmonary, Allergy and Critical Care Medicine Emory University Atlanta Georgia USADivision of Pulmonary, Allergy and Critical Care Medicine Emory University Atlanta Georgia USADivision of Pulmonary, Allergy and Critical Care Medicine Emory University Atlanta Georgia USAThe Center for Integrative Environmental Health Sciences University of Louisville Louisville Kentucky USADepartment of Anesthesiology and Perioperative Medicine University of Louisville School of Medicine Louisville Kentucky USAAbstract Pulmonary arterial hypertension (PAH) prevalence is increasing worldwide, and the prognosis is poor with 5‐year survival < 50% in high risk patients. The relationship between metal exposure/essential metal dyshomeostasis and PAH/right ventricular dysfunction is less investigated. The aim of this study is to investigate vegetable consumptions and metal levels between PAH patients and controls. This was a prospective, single center pilot study. Questionnaires were completed by all study subjects (20 PAH patients and 10 healthy controls) on smoking, metal exposure risks, metal supplements, and vegetable consumptions. Blood and urine samples were collected to measure 25 metal levels in blood, plasma, and urine using an X Series II quadrupole inductively coupled plasma mass spectrometry. Statistical analysis was conducted using SAS 9.5 and results with p value < 0.05 were considered significant. Vegetables consumptions (broccoli risk ratio [RR] = 0.4, CI = (0.2, 0.9)], cabbage [RR = 0.2, CI = (0.1, 0.8)], and brussel sprouts [RR = 0.2, CI = (0.1, 0.5)]) are associated with less risks of PAH. In the plasma samples, silver (p < 0.001), and copper (p = 0.002) levels were significantly higher in PAH patients. There was significant positive correlation between cardiac output and cardiac index with plasma levels of silver (r = 0.665, p = 0.001 and r = 0.678 p = 0.001), respectively. There was significant correlation between mixed venous saturation, 6‐min walk distance, and last BNP with plasma levels of chromium (r = −0.520, p = 0.022; r = −0.55, p = 0.014; r = 0.463, p = 0.039), respectively. In conclusion, there are significant differences between PAH and control groups in terms of vegetable consumptions and metal concentrations. Silver and chromium levels are correlated with clinical indicators of PAH severities.https://doi.org/10.1002/pul2.12202chromiumcoppermetalpulmonary hypertensionsilver |
| spellingShingle | Karim El‐Kersh C. Danielle Hopkins Xiaoyong Wu Shesh N. Rai Matthew C. Cave M. Ryan Smith Young‐Mi Go Dean P. Jones Lu Cai Jiapeng Huang Metallomics in pulmonary arterial hypertension patients Pulmonary Circulation chromium copper metal pulmonary hypertension silver |
| title | Metallomics in pulmonary arterial hypertension patients |
| title_full | Metallomics in pulmonary arterial hypertension patients |
| title_fullStr | Metallomics in pulmonary arterial hypertension patients |
| title_full_unstemmed | Metallomics in pulmonary arterial hypertension patients |
| title_short | Metallomics in pulmonary arterial hypertension patients |
| title_sort | metallomics in pulmonary arterial hypertension patients |
| topic | chromium copper metal pulmonary hypertension silver |
| url | https://doi.org/10.1002/pul2.12202 |
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