METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES
52 pulmonary tuberculosis patients with concurrent diabetes and 76 pulmonary tuberculosis patients without concurrent diabetes (control group) were examined. The state of vascular endothelium was evaluated by the content of nitrogen oxide (NO), endothelium-1 (E-1) and antigen of Willebrand factor (W...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2015-10-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/809 |
| _version_ | 1797696714848600064 |
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| author | G. O. Kaminskaya R. Yu. Abdullaev O. G. Komissarova O. O. Konyaeva O. O. Berezhnaya |
| author_facet | G. O. Kaminskaya R. Yu. Abdullaev O. G. Komissarova O. O. Konyaeva O. O. Berezhnaya |
| author_sort | G. O. Kaminskaya |
| collection | DOAJ |
| description | 52 pulmonary tuberculosis patients with concurrent diabetes and 76 pulmonary tuberculosis patients without concurrent diabetes (control group) were examined. The state of vascular endothelium was evaluated by the content of nitrogen oxide (NO), endothelium-1 (E-1) and antigen of Willebrand factor (WF) in blood serum (plasma). Patients with concurrent condition had more significant changes in their metabolic status of vascular endothelium (endothelial dysfunction) compared to control group. It manifested through significant reduction of NO level, which is negatively correlated to the increase of glycosylated hemoglobin and the loss of the self-regulating ability of the endothelium cells. The latter was documented by development of the negative correlation between rates of NO and E-1 (in the comparison group the correlation was positive). Functional decompensation of vascular endothelium in pulmonary tuberculosis patients with concurrent diabetes was accompanied by the presence of endothelial destructive lesions, documented increase of WF (in the majority of patients from the control group WF was within the upper limit of the referent rates). In 3 months of complex treatment of patients with concurrent pathology NO level became normal, but E-1 and WF went confidently down but still were above the upper limits of the norm. |
| first_indexed | 2024-03-12T03:30:17Z |
| format | Article |
| id | doaj.art-df316f89868d45b5abb41c4c08419e7a |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T03:30:17Z |
| publishDate | 2015-10-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-df316f89868d45b5abb41c4c08419e7a2023-09-03T13:29:15ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-10-010105863809METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETESG. O. Kaminskaya0R. Yu. Abdullaev1O. G. Komissarova2O. O. Konyaeva3O. O. Berezhnaya4ФГБНУ «Центральный НИИ туберкулеза», г. МоскваФГБНУ «Центральный НИИ туберкулеза», г. МоскваФГБНУ «Центральный НИИ туберкулеза», г. Москва; Российский национальный исследовательский медицинский университет им. Н. И. Пирогова, г. МоскваФГБНУ «Центральный НИИ туберкулеза», г. МоскваФГБНУ «Центральный НИИ туберкулеза», г. Москва; Российский национальный исследовательский медицинский университет им. Н. И. Пирогова, г. Москва52 pulmonary tuberculosis patients with concurrent diabetes and 76 pulmonary tuberculosis patients without concurrent diabetes (control group) were examined. The state of vascular endothelium was evaluated by the content of nitrogen oxide (NO), endothelium-1 (E-1) and antigen of Willebrand factor (WF) in blood serum (plasma). Patients with concurrent condition had more significant changes in their metabolic status of vascular endothelium (endothelial dysfunction) compared to control group. It manifested through significant reduction of NO level, which is negatively correlated to the increase of glycosylated hemoglobin and the loss of the self-regulating ability of the endothelium cells. The latter was documented by development of the negative correlation between rates of NO and E-1 (in the comparison group the correlation was positive). Functional decompensation of vascular endothelium in pulmonary tuberculosis patients with concurrent diabetes was accompanied by the presence of endothelial destructive lesions, documented increase of WF (in the majority of patients from the control group WF was within the upper limit of the referent rates). In 3 months of complex treatment of patients with concurrent pathology NO level became normal, but E-1 and WF went confidently down but still were above the upper limits of the norm.https://www.tibl-journal.com/jour/article/view/809туберкулез легкихсахарный диабетдисфункция эндотелияоксид азотаэндотелин-1фактор виллебранда |
| spellingShingle | G. O. Kaminskaya R. Yu. Abdullaev O. G. Komissarova O. O. Konyaeva O. O. Berezhnaya METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES Туберкулез и болезни лёгких туберкулез легких сахарный диабет дисфункция эндотелия оксид азота эндотелин-1 фактор виллебранда |
| title | METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES |
| title_full | METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES |
| title_fullStr | METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES |
| title_full_unstemmed | METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES |
| title_short | METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES |
| title_sort | metabolic status of vascular endothelium in pulmonary tuberculosis patients with concurrent diabetes |
| topic | туберкулез легких сахарный диабет дисфункция эндотелия оксид азота эндотелин-1 фактор виллебранда |
| url | https://www.tibl-journal.com/jour/article/view/809 |
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