Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review
Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the ra...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/5/1100 |
| _version_ | 1797475578542030848 |
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| author | Sareh Kamran Ajantha Sinniah Mahfoudh A. M. Abdulghani Mohammed Abdullah Alshawsh |
| author_facet | Sareh Kamran Ajantha Sinniah Mahfoudh A. M. Abdulghani Mohammed Abdullah Alshawsh |
| author_sort | Sareh Kamran |
| collection | DOAJ |
| description | Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. Hence, in this review, the anticancer activities of twenty-five terpenoids are discussed in detail. In addition, this review provides insights on the current clinical trials and future directions towards the development of certain terpenoids as potential anticancer agents. |
| first_indexed | 2024-03-09T20:46:08Z |
| format | Article |
| id | doaj.art-df3652dd779140058189ed8ddf972dfa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:46:08Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-df3652dd779140058189ed8ddf972dfa2023-11-23T22:45:52ZengMDPI AGCancers2072-66942022-02-01145110010.3390/cancers14051100Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping ReviewSareh Kamran0Ajantha Sinniah1Mahfoudh A. M. Abdulghani2Mohammed Abdullah Alshawsh3Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Al Qassim 51911, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaCancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. Hence, in this review, the anticancer activities of twenty-five terpenoids are discussed in detail. In addition, this review provides insights on the current clinical trials and future directions towards the development of certain terpenoids as potential anticancer agents.https://www.mdpi.com/2072-6694/14/5/1100cancerterpenoidsmolecular mechanismterpeneschemosensitization |
| spellingShingle | Sareh Kamran Ajantha Sinniah Mahfoudh A. M. Abdulghani Mohammed Abdullah Alshawsh Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review Cancers cancer terpenoids molecular mechanism terpenes chemosensitization |
| title | Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review |
| title_full | Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review |
| title_fullStr | Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review |
| title_full_unstemmed | Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review |
| title_short | Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review |
| title_sort | therapeutic potential of certain terpenoids as anticancer agents a scoping review |
| topic | cancer terpenoids molecular mechanism terpenes chemosensitization |
| url | https://www.mdpi.com/2072-6694/14/5/1100 |
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