Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study
BackgroundTopiramate (TPM) may reduce olanzapine (OLZ)-related weight gain and metabolism abnormalities in patients with schizophrenia. However, differences in the efficacy of OLZ-related weight gain and metabolism abnormalities between TPM and vitamin C (VC) are not clear. This study aimed to inves...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1152953/full |
| _version_ | 1797829038351319040 |
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| author | Jinling Zhang Shu Chen Jia Chen Handi Zhang Wen-Wang Rao |
| author_facet | Jinling Zhang Shu Chen Jia Chen Handi Zhang Wen-Wang Rao |
| author_sort | Jinling Zhang |
| collection | DOAJ |
| description | BackgroundTopiramate (TPM) may reduce olanzapine (OLZ)-related weight gain and metabolism abnormalities in patients with schizophrenia. However, differences in the efficacy of OLZ-related weight gain and metabolism abnormalities between TPM and vitamin C (VC) are not clear. This study aimed to investigate whether TPM is more effective than VC in reducing OLZ-induced weight gain and metabolic abnormalities in patients with schizophrenia and explore their patterns.MethodsThis was a 12-week longitudinal comparison study in OLZ-treated patients with schizophrenia. Twenty-two patients who received OLZ monotherapy plus VC treatment (OLZ + VC group) was matched to 22 patients who received OLZ monotherapy plus TPM treatment (OLZ + TPM group). Body mass index (BMI) and metabolism indicators were measured at baseline and 12-weeks follow-up.ResultsA significant difference in triglyceride (TG) levels at different time points (pre-treatment: F = 7.89, p = 0.008; 4-weeks treatment: F = 13.19, p = 0.001; 12-weeks treatment: F = 54.48, p < 0.001) was found. Latent profile analysis demonstrated that a 2-class model for OLZ + TPM group (high vs. low BMI in the first 4 weeks) and OLZ + VC group (high vs. low), respectively.ConclusionOur findings suggested that TPM could better mitigates OLZ-induced increase in TG levels. The trajectories of change also differed in all metabolic indexes over time between the two groups. |
| first_indexed | 2024-04-09T13:13:59Z |
| format | Article |
| id | doaj.art-df368d72c270439895d2ed696f1d3f59 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T13:13:59Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-df368d72c270439895d2ed696f1d3f592023-05-12T05:45:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-05-011410.3389/fpsyt.2023.11529531152953Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary studyJinling Zhang0Shu Chen1Jia Chen2Handi Zhang3Wen-Wang Rao4Mental Health Center of Shantou University, Shantou, Guangdong, ChinaThe Fourth People's Hospital of Chengdu, Chengdu, Sichuan, ChinaThe Fourth People's Hospital of Chengdu, Chengdu, Sichuan, ChinaMental Health Center of Shantou University, Shantou, Guangdong, ChinaDepartment of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong, ChinaBackgroundTopiramate (TPM) may reduce olanzapine (OLZ)-related weight gain and metabolism abnormalities in patients with schizophrenia. However, differences in the efficacy of OLZ-related weight gain and metabolism abnormalities between TPM and vitamin C (VC) are not clear. This study aimed to investigate whether TPM is more effective than VC in reducing OLZ-induced weight gain and metabolic abnormalities in patients with schizophrenia and explore their patterns.MethodsThis was a 12-week longitudinal comparison study in OLZ-treated patients with schizophrenia. Twenty-two patients who received OLZ monotherapy plus VC treatment (OLZ + VC group) was matched to 22 patients who received OLZ monotherapy plus TPM treatment (OLZ + TPM group). Body mass index (BMI) and metabolism indicators were measured at baseline and 12-weeks follow-up.ResultsA significant difference in triglyceride (TG) levels at different time points (pre-treatment: F = 7.89, p = 0.008; 4-weeks treatment: F = 13.19, p = 0.001; 12-weeks treatment: F = 54.48, p < 0.001) was found. Latent profile analysis demonstrated that a 2-class model for OLZ + TPM group (high vs. low BMI in the first 4 weeks) and OLZ + VC group (high vs. low), respectively.ConclusionOur findings suggested that TPM could better mitigates OLZ-induced increase in TG levels. The trajectories of change also differed in all metabolic indexes over time between the two groups.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1152953/fulltopiramatevitamin Colanzapineweight gainmetabolism abnormalitiesschizophrenia |
| spellingShingle | Jinling Zhang Shu Chen Jia Chen Handi Zhang Wen-Wang Rao Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study Frontiers in Psychiatry topiramate vitamin C olanzapine weight gain metabolism abnormalities schizophrenia |
| title | Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study |
| title_full | Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study |
| title_fullStr | Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study |
| title_full_unstemmed | Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study |
| title_short | Comparison of olanzapine-induced weight gain and metabolism abnormalities between topiramate and vitamin C in patients with schizophrenia: a preliminary study |
| title_sort | comparison of olanzapine induced weight gain and metabolism abnormalities between topiramate and vitamin c in patients with schizophrenia a preliminary study |
| topic | topiramate vitamin C olanzapine weight gain metabolism abnormalities schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1152953/full |
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