Animal models for research on endometriosis
Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-10-01
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| Series: | Frontiers in Bioscience-Elite |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBE/13/1/10.2741/871 |
| _version_ | 1818243007106777088 |
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| author | Fuminori Taniguchi Hermawan Wibisono Yin Mon Khine Tasuku Harada |
| author_facet | Fuminori Taniguchi Hermawan Wibisono Yin Mon Khine Tasuku Harada |
| author_sort | Fuminori Taniguchi |
| collection | DOAJ |
| description | Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice or using homologous mouse models. Here, we examine the murine models of endometriosis, the impact of forced induced inflammation on its development, similarities in the gene expression profile in the endometriotic tissues in such models with that seen in human endometriosis, and the drugs that are being used in such models as potential new treatment for endometriosis |
| first_indexed | 2024-12-12T13:54:16Z |
| format | Article |
| id | doaj.art-df36b4efe46f43558f78350ecfd0a261 |
| institution | Directory Open Access Journal |
| issn | 1945-0494 |
| language | English |
| last_indexed | 2024-12-12T13:54:16Z |
| publishDate | 2020-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Elite |
| spelling | doaj.art-df36b4efe46f43558f78350ecfd0a2612022-12-22T00:22:30ZengIMR PressFrontiers in Bioscience-Elite1945-04942020-10-01131375310.2741/871S1945-0494(21)00002-3Animal models for research on endometriosisFuminori Taniguchi0Hermawan Wibisono1Yin Mon Khine2Tasuku Harada3Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, 683-8504, JapanDepartment of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, 683-8504, JapanDepartment of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, 683-8504, JapanDepartment of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, 683-8504, JapanEndometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice or using homologous mouse models. Here, we examine the murine models of endometriosis, the impact of forced induced inflammation on its development, similarities in the gene expression profile in the endometriotic tissues in such models with that seen in human endometriosis, and the drugs that are being used in such models as potential new treatment for endometriosishttps://www.imrpress.com/journal/FBE/13/1/10.2741/871endometriosismurine endometriosis-like lesionexperimental modelcystic lesionreview |
| spellingShingle | Fuminori Taniguchi Hermawan Wibisono Yin Mon Khine Tasuku Harada Animal models for research on endometriosis Frontiers in Bioscience-Elite endometriosis murine endometriosis-like lesion experimental model cystic lesion review |
| title | Animal models for research on endometriosis |
| title_full | Animal models for research on endometriosis |
| title_fullStr | Animal models for research on endometriosis |
| title_full_unstemmed | Animal models for research on endometriosis |
| title_short | Animal models for research on endometriosis |
| title_sort | animal models for research on endometriosis |
| topic | endometriosis murine endometriosis-like lesion experimental model cystic lesion review |
| url | https://www.imrpress.com/journal/FBE/13/1/10.2741/871 |
| work_keys_str_mv | AT fuminoritaniguchi animalmodelsforresearchonendometriosis AT hermawanwibisono animalmodelsforresearchonendometriosis AT yinmonkhine animalmodelsforresearchonendometriosis AT tasukuharada animalmodelsforresearchonendometriosis |