The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China
ABSTRACTGenetic changes have occurred in the genomes of prevalent African swine fever viruses (ASFVs) in the field in China, which may change their antigenic properties and result in immune escape. There is usually poor cross-protection between heterogonous isolates, and, therefore, it is important...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2300464 |
| _version_ | 1797348791171416064 |
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| author | Zilong Wang Jiwen Zhang Fang Li Zhenjiang Zhang Weiye Chen Xianfeng Zhang Encheng Sun Yuanmao Zhu Renqiang Liu Xijun He Zhigao Bu Dongming Zhao |
| author_facet | Zilong Wang Jiwen Zhang Fang Li Zhenjiang Zhang Weiye Chen Xianfeng Zhang Encheng Sun Yuanmao Zhu Renqiang Liu Xijun He Zhigao Bu Dongming Zhao |
| author_sort | Zilong Wang |
| collection | DOAJ |
| description | ABSTRACTGenetic changes have occurred in the genomes of prevalent African swine fever viruses (ASFVs) in the field in China, which may change their antigenic properties and result in immune escape. There is usually poor cross-protection between heterogonous isolates, and, therefore, it is important to test the cross-protection of the live attenuated ASFV vaccines against current prevalent heterogonous isolates. In this study, we evaluated the protective efficacy of the ASFV vaccine candidate HLJ/18-7GD against emerging isolates. HLJ/18-7GD provided protection against a highly virulent variant and a lower lethal isolate, both derived from genotype II Georgia07-like ASFV and isolated in 2020. HLJ/18-7GD vaccination prevented pigs from developing ASF-specific clinical signs and death, decreased viral shedding via the oral and rectal routes, and suppressed viral replication after challenges. However, HLJ/18-7GD vaccination did not provide solid cross-protection against genotype I NH/P68-like ASFV challenge in pigs. HLJ/18-7GD vaccination thus shows great promise as an alternative strategy for preventing and controlling genotype II ASFVs, but vaccines providing cross-protection against different ASFV genotypes may be needed in China. |
| first_indexed | 2024-03-08T12:11:13Z |
| format | Article |
| id | doaj.art-df3826bd5d4441b6a16683844d5451c7 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T12:11:13Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-df3826bd5d4441b6a16683844d5451c72024-01-22T22:29:36ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2300464The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in ChinaZilong Wang0Jiwen Zhang1Fang Li2Zhenjiang Zhang3Weiye Chen4Xianfeng Zhang5Encheng Sun6Yuanmao Zhu7Renqiang Liu8Xijun He9Zhigao Bu10Dongming Zhao11State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaABSTRACTGenetic changes have occurred in the genomes of prevalent African swine fever viruses (ASFVs) in the field in China, which may change their antigenic properties and result in immune escape. There is usually poor cross-protection between heterogonous isolates, and, therefore, it is important to test the cross-protection of the live attenuated ASFV vaccines against current prevalent heterogonous isolates. In this study, we evaluated the protective efficacy of the ASFV vaccine candidate HLJ/18-7GD against emerging isolates. HLJ/18-7GD provided protection against a highly virulent variant and a lower lethal isolate, both derived from genotype II Georgia07-like ASFV and isolated in 2020. HLJ/18-7GD vaccination prevented pigs from developing ASF-specific clinical signs and death, decreased viral shedding via the oral and rectal routes, and suppressed viral replication after challenges. However, HLJ/18-7GD vaccination did not provide solid cross-protection against genotype I NH/P68-like ASFV challenge in pigs. HLJ/18-7GD vaccination thus shows great promise as an alternative strategy for preventing and controlling genotype II ASFVs, but vaccines providing cross-protection against different ASFV genotypes may be needed in China.https://www.tandfonline.com/doi/10.1080/22221751.2023.2300464African swine fever viruslive attenuated vaccinecross-protectionfield prevalent isolate |
| spellingShingle | Zilong Wang Jiwen Zhang Fang Li Zhenjiang Zhang Weiye Chen Xianfeng Zhang Encheng Sun Yuanmao Zhu Renqiang Liu Xijun He Zhigao Bu Dongming Zhao The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China Emerging Microbes and Infections African swine fever virus live attenuated vaccine cross-protection field prevalent isolate |
| title | The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China |
| title_full | The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China |
| title_fullStr | The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China |
| title_full_unstemmed | The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China |
| title_short | The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China |
| title_sort | attenuated african swine fever vaccine hlj 18 7gd provides protection against emerging prevalent genotype ii variants in china |
| topic | African swine fever virus live attenuated vaccine cross-protection field prevalent isolate |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2300464 |
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