Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023
BackgroundCervical cancer is primarily caused by HPV infection. The epidemiology of HPV infection in specific areas is of great meaning of guide cervical cancer screening and formulating HPV vaccination strategies. Here, we evaluated the epidemiological characteristics of HPV infection in Xiamen pop...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1332696/full |
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| author | Xingmei Yao Qing Li Yu Chen Zhuowen Du Yanru Huang Yixi Zhou Jian Zhang Wenbo Wang Lutan Zhang Jieqiong Xie Chao Xu Yunsheng Ge Yulin Zhou Yulin Zhou |
| author_facet | Xingmei Yao Qing Li Yu Chen Zhuowen Du Yanru Huang Yixi Zhou Jian Zhang Wenbo Wang Lutan Zhang Jieqiong Xie Chao Xu Yunsheng Ge Yulin Zhou Yulin Zhou |
| author_sort | Xingmei Yao |
| collection | DOAJ |
| description | BackgroundCervical cancer is primarily caused by HPV infection. The epidemiology of HPV infection in specific areas is of great meaning of guide cervical cancer screening and formulating HPV vaccination strategies. Here, we evaluated the epidemiological characteristics of HPV infection in Xiamen population.MethodsIn total, 159,049 cervical exfoliated cell samples collected from female outpatients in Women and Children’s Hospital, School of Medicine, Xiamen between January 2013 and July 2023 were analyzed. HPV DNA detection was performed using HPV genotyping kits (Hybribio Limited Corp, China). An analysis was conducted on the prevalence of HPV infection, taking into account factors such as age, year, and multiple patterns of HPV infection. The differences in prevalence among age groups and years were compared using χ2 test.ResultsThe overall prevalence of any 21 HPV genotypes was 18.4%, of which the high-risk HPV (HR-HPV) positive rate was 14.6%. The age-specific prevalence of HPV infection showed a bimodal distribution, with two distinct peaks, one at <25 years (31.2%) and the other at 60–64 years (32.9%). There was a downward trend in the prevalence of HPV infection over time, decreasing from 26.2% in 2013 to 14.5% in 2021, and then increasing to 19.0% in 2023. The five most prevent HR-HPV genotypes were HPV52 (4.0%), 58 (2.6%), 16 (2.5%), 51 (1.8%), and 39 (1.7%). Among the positive cases, 76.7% were detected with only one genotype and 23.3% with multiple genotypes. The most common co-infection was HPV52 + HPV58 (0.24%), followed by HPV16 + HPV52 (0.24%), HPV52 + HPV53 (0.21%), HPV52 + HPV81 (0.21%), HPV51 + HPV52 (0.19%), HPV16 + HPV58 (0.18%), and HPV39 + HPV52 (0.17%).ConclusionThe study provided the largest scale information on the recent epidemiological characteristics of HPV infection in Xiamen, and even in Fujian Province, China, which would support making the prevention and control strategies for cervical cancer in the region. |
| first_indexed | 2024-04-24T19:38:02Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T19:38:02Z |
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| series | Frontiers in Public Health |
| spelling | doaj.art-df38351972794dc38debaa7103298a3f2024-03-25T12:10:12ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-03-011210.3389/fpubh.2024.13326961332696Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023Xingmei Yao0Qing Li1Yu Chen2Zhuowen Du3Yanru Huang4Yixi Zhou5Jian Zhang6Wenbo Wang7Lutan Zhang8Jieqiong Xie9Chao Xu10Yunsheng Ge11Yulin Zhou12Yulin Zhou13Department of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Women Health Care, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaUnited Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, ChinaUnited Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Information Center, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Central Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaUnited Diagnostic and Research Center for Clinical Genetics, Women and Children’s Hospital, School of Medicine and School of Public Health, Xiamen University, Xiamen, Fujian, ChinaBackgroundCervical cancer is primarily caused by HPV infection. The epidemiology of HPV infection in specific areas is of great meaning of guide cervical cancer screening and formulating HPV vaccination strategies. Here, we evaluated the epidemiological characteristics of HPV infection in Xiamen population.MethodsIn total, 159,049 cervical exfoliated cell samples collected from female outpatients in Women and Children’s Hospital, School of Medicine, Xiamen between January 2013 and July 2023 were analyzed. HPV DNA detection was performed using HPV genotyping kits (Hybribio Limited Corp, China). An analysis was conducted on the prevalence of HPV infection, taking into account factors such as age, year, and multiple patterns of HPV infection. The differences in prevalence among age groups and years were compared using χ2 test.ResultsThe overall prevalence of any 21 HPV genotypes was 18.4%, of which the high-risk HPV (HR-HPV) positive rate was 14.6%. The age-specific prevalence of HPV infection showed a bimodal distribution, with two distinct peaks, one at <25 years (31.2%) and the other at 60–64 years (32.9%). There was a downward trend in the prevalence of HPV infection over time, decreasing from 26.2% in 2013 to 14.5% in 2021, and then increasing to 19.0% in 2023. The five most prevent HR-HPV genotypes were HPV52 (4.0%), 58 (2.6%), 16 (2.5%), 51 (1.8%), and 39 (1.7%). Among the positive cases, 76.7% were detected with only one genotype and 23.3% with multiple genotypes. The most common co-infection was HPV52 + HPV58 (0.24%), followed by HPV16 + HPV52 (0.24%), HPV52 + HPV53 (0.21%), HPV52 + HPV81 (0.21%), HPV51 + HPV52 (0.19%), HPV16 + HPV58 (0.18%), and HPV39 + HPV52 (0.17%).ConclusionThe study provided the largest scale information on the recent epidemiological characteristics of HPV infection in Xiamen, and even in Fujian Province, China, which would support making the prevention and control strategies for cervical cancer in the region.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1332696/fullhuman papillomavirus (HPV)infectiongenotypeprevalencecervical cancer |
| spellingShingle | Xingmei Yao Qing Li Yu Chen Zhuowen Du Yanru Huang Yixi Zhou Jian Zhang Wenbo Wang Lutan Zhang Jieqiong Xie Chao Xu Yunsheng Ge Yulin Zhou Yulin Zhou Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 Frontiers in Public Health human papillomavirus (HPV) infection genotype prevalence cervical cancer |
| title | Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 |
| title_full | Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 |
| title_fullStr | Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 |
| title_full_unstemmed | Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 |
| title_short | Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023 |
| title_sort | epidemiology of human papillomavirus infection in women from xiamen china 2013 to 2023 |
| topic | human papillomavirus (HPV) infection genotype prevalence cervical cancer |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1332696/full |
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