Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Background/Aims This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each cla...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-05-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2017-332.pdf |
| _version_ | 1819081437277585408 |
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| author | Bongyoung Kim Hyeonjun Hwang Jieun Kim Myoung-jae Lee Hyunjoo Pai |
| author_facet | Bongyoung Kim Hyeonjun Hwang Jieun Kim Myoung-jae Lee Hyunjoo Pai |
| author_sort | Bongyoung Kim |
| collection | DOAJ |
| description | Background/Aims This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend. |
| first_indexed | 2024-12-21T20:00:46Z |
| format | Article |
| id | doaj.art-df38abdf48ca4a1a8b71ff03ec212973 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-21T20:00:46Z |
| publishDate | 2020-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-df38abdf48ca4a1a8b71ff03ec2129732022-12-21T18:51:59ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-05-0135370371310.3904/kjim.2017.332170113Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013Bongyoung Kim0Hyeonjun Hwang1Jieun Kim2Myoung-jae Lee3Hyunjoo Pai4 Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea School of Economic Sciences, Washington State University, Pullman, WA, USA Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Economics, Korea University College of Political Science and Economics, Seoul, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, KoreaBackground/Aims This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.http://www.kjim.org/upload/pdf/kjim-2017-332.pdfanti-bacterial agentshospitalskorea |
| spellingShingle | Bongyoung Kim Hyeonjun Hwang Jieun Kim Myoung-jae Lee Hyunjoo Pai Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 The Korean Journal of Internal Medicine anti-bacterial agents hospitals korea |
| title | Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 |
| title_full | Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 |
| title_fullStr | Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 |
| title_full_unstemmed | Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 |
| title_short | Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013 |
| title_sort | ten year trends in antibiotic usage at a tertiary care hospital in korea 2004 to 2013 |
| topic | anti-bacterial agents hospitals korea |
| url | http://www.kjim.org/upload/pdf/kjim-2017-332.pdf |
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