Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms
In the paper, we propose a procedure to be used for the validation of software for forward modeling of rat electroencephalogram with scalp potentials measured on rat head phantoms. Measurements are performed on a cuboidal phantom, a simplified shape of a rat brain, and an anatomically realistic, com...
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9868355/ |
| _version_ | 1798003313940103168 |
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| author | David Kuratko Jaroslav Lacik Vlastimil Koudelka Cestmir Vejmola Daniel Krzysztof Wojcik Zbynek Raida |
| author_facet | David Kuratko Jaroslav Lacik Vlastimil Koudelka Cestmir Vejmola Daniel Krzysztof Wojcik Zbynek Raida |
| author_sort | David Kuratko |
| collection | DOAJ |
| description | In the paper, we propose a procedure to be used for the validation of software for forward modeling of rat electroencephalogram with scalp potentials measured on rat head phantoms. Measurements are performed on a cuboidal phantom, a simplified shape of a rat brain, and an anatomically realistic, computed tomography (CT)-based phantom considering the brain and the skull. The physical phantoms are composed of an agar mixture to mimic the rat brain, excitation dipoles for modeling the neural activity of the brain, electrodes for monitoring the surface electric potential and a 3D printed skull. To ensure correct positions of dipoles and electrodes for numerical simulations, the phantoms are scanned by a computed tomography. After that, reconstructed 3D models are simulated in three EM solvers and results are compared with EEG measurements. Differences between simulations and measurements are further analyzed by parametric simulations and discussed. Obtained results provide the software validation method for rat brain forward modeling. Properly validated computation of electric potentials is essential for development of electrical brain stimulation protocols as well as in optimization of electrode placement. |
| first_indexed | 2024-04-11T12:06:40Z |
| format | Article |
| id | doaj.art-df3a98f527804405a99e1635923bbe17 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-04-11T12:06:40Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-df3a98f527804405a99e1635923bbe172022-12-22T04:24:43ZengIEEEIEEE Access2169-35362022-01-0110920239203510.1109/ACCESS.2022.32022069868355Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head PhantomsDavid Kuratko0https://orcid.org/0000-0002-0493-1625Jaroslav Lacik1https://orcid.org/0000-0002-8010-6977Vlastimil Koudelka2https://orcid.org/0000-0002-7553-7529Cestmir Vejmola3https://orcid.org/0000-0002-6434-5978Daniel Krzysztof Wojcik4https://orcid.org/0000-0003-0812-9872Zbynek Raida5https://orcid.org/0000-0003-4466-5496Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech RepublicFaculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech RepublicNational Institute of Mental Health, Klecany, Czech RepublicNational Institute of Mental Health, Klecany, Czech RepublicFaculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech RepublicFaculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech RepublicIn the paper, we propose a procedure to be used for the validation of software for forward modeling of rat electroencephalogram with scalp potentials measured on rat head phantoms. Measurements are performed on a cuboidal phantom, a simplified shape of a rat brain, and an anatomically realistic, computed tomography (CT)-based phantom considering the brain and the skull. The physical phantoms are composed of an agar mixture to mimic the rat brain, excitation dipoles for modeling the neural activity of the brain, electrodes for monitoring the surface electric potential and a 3D printed skull. To ensure correct positions of dipoles and electrodes for numerical simulations, the phantoms are scanned by a computed tomography. After that, reconstructed 3D models are simulated in three EM solvers and results are compared with EEG measurements. Differences between simulations and measurements are further analyzed by parametric simulations and discussed. Obtained results provide the software validation method for rat brain forward modeling. Properly validated computation of electric potentials is essential for development of electrical brain stimulation protocols as well as in optimization of electrode placement.https://ieeexplore.ieee.org/document/9868355/Forward modelCT-based rat head phantomnumerical simulationvalidation studies |
| spellingShingle | David Kuratko Jaroslav Lacik Vlastimil Koudelka Cestmir Vejmola Daniel Krzysztof Wojcik Zbynek Raida Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms IEEE Access Forward model CT-based rat head phantom numerical simulation validation studies |
| title | Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms |
| title_full | Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms |
| title_fullStr | Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms |
| title_full_unstemmed | Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms |
| title_short | Forward Model of Rat Electroencephalogram: Comparative Study of Numerical Simulations With Measurements on Rat Head Phantoms |
| title_sort | forward model of rat electroencephalogram comparative study of numerical simulations with measurements on rat head phantoms |
| topic | Forward model CT-based rat head phantom numerical simulation validation studies |
| url | https://ieeexplore.ieee.org/document/9868355/ |
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