Alteration of indicator gut microbiota in patients with chronic sinusitis
Abstract Background Many factors influence the composition of the sinus microflora. The microbial balance is most disturbed by the use of antibacterial agents. Superinfections caused by more than one pathogen may then occur. Despite treatment, including surgery and long‐term antibiotic therapy, many...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.996 |
| _version_ | 1797670749515808768 |
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| author | Michał Michalik Adrianna Podbielska‐Kubera Anna Maria Basińska Monika Szewc Mirosława Gałęcka Andreas Schwiertz |
| author_facet | Michał Michalik Adrianna Podbielska‐Kubera Anna Maria Basińska Monika Szewc Mirosława Gałęcka Andreas Schwiertz |
| author_sort | Michał Michalik |
| collection | DOAJ |
| description | Abstract Background Many factors influence the composition of the sinus microflora. The microbial balance is most disturbed by the use of antibacterial agents. Superinfections caused by more than one pathogen may then occur. Despite treatment, including surgery and long‐term antibiotic therapy, many patients with sinusitis do not experience significant relief from their symptoms. It has been hypothesized that an imbalance in the gut microbiota may also be responsible for the chronicity of sinusitis. Our goal was therefore to identify selected gut indicator bacteria that play a role in immunity in patients with chronic sinusitis. In addition, compare the number of selected bacteria in two groups of patients: with chronic sinusitis and with chronic rhinosinusitis (CRS) with concomitant diseases and/or symptoms other than CRS. Results Significantly decreased numbers of Bifidobacterium spp. and Faecalibacterium prauznitzi bacteria were observed in patients from the G1 group. The majority of patients from this group (12 out of 13) had a significantly decreased number of Bifidobacterium and Akkermansia muciniphila bacteria, which are involved in the nutrition and regeneration of gut epithelium cells and have anti‐inflammatory properties. In group G2 (patients with chronic sinusitis and symptoms of comorbidities) a decreased number of F. prausnitzii, Bifidobacterium spp., A. muciniphila and Lactobacillus spp. bacteria was observed. A small percentage of patients in this group showed overgrowth of yeast‐like fungi. Conclusion Although the more research is needed, possibly the gut microbiota indicator bacteria number analyses might enable to plan personalized prebiotic and probiotic treatment, which could support intestine microbiota and mucosal immunity patients suffering from chronic sinusitis. |
| first_indexed | 2024-03-11T21:04:05Z |
| format | Article |
| id | doaj.art-df3fafa72b1b4b7892cf64efa1199581 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-11T21:04:05Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-df3fafa72b1b4b7892cf64efa11995812023-09-29T16:08:31ZengWileyImmunity, Inflammation and Disease2050-45272023-09-01119n/an/a10.1002/iid3.996Alteration of indicator gut microbiota in patients with chronic sinusitisMichał Michalik0Adrianna Podbielska‐Kubera1Anna Maria Basińska2Monika Szewc3Mirosława Gałęcka4Andreas Schwiertz5MML Medical Center Warsaw PolandMML Medical Center Warsaw PolandInstitute of Microecology Poznań PolandInstitute of Microecology Poznań PolandInstitute of Microecology Poznań PolandInstitute of Microecology Herborn GermanyAbstract Background Many factors influence the composition of the sinus microflora. The microbial balance is most disturbed by the use of antibacterial agents. Superinfections caused by more than one pathogen may then occur. Despite treatment, including surgery and long‐term antibiotic therapy, many patients with sinusitis do not experience significant relief from their symptoms. It has been hypothesized that an imbalance in the gut microbiota may also be responsible for the chronicity of sinusitis. Our goal was therefore to identify selected gut indicator bacteria that play a role in immunity in patients with chronic sinusitis. In addition, compare the number of selected bacteria in two groups of patients: with chronic sinusitis and with chronic rhinosinusitis (CRS) with concomitant diseases and/or symptoms other than CRS. Results Significantly decreased numbers of Bifidobacterium spp. and Faecalibacterium prauznitzi bacteria were observed in patients from the G1 group. The majority of patients from this group (12 out of 13) had a significantly decreased number of Bifidobacterium and Akkermansia muciniphila bacteria, which are involved in the nutrition and regeneration of gut epithelium cells and have anti‐inflammatory properties. In group G2 (patients with chronic sinusitis and symptoms of comorbidities) a decreased number of F. prausnitzii, Bifidobacterium spp., A. muciniphila and Lactobacillus spp. bacteria was observed. A small percentage of patients in this group showed overgrowth of yeast‐like fungi. Conclusion Although the more research is needed, possibly the gut microbiota indicator bacteria number analyses might enable to plan personalized prebiotic and probiotic treatment, which could support intestine microbiota and mucosal immunity patients suffering from chronic sinusitis.https://doi.org/10.1002/iid3.996autoimmunological or allergic symptomschronic rhinosinusitis (CRS)immunityintestinal microbiotamicrobiological indicator |
| spellingShingle | Michał Michalik Adrianna Podbielska‐Kubera Anna Maria Basińska Monika Szewc Mirosława Gałęcka Andreas Schwiertz Alteration of indicator gut microbiota in patients with chronic sinusitis Immunity, Inflammation and Disease autoimmunological or allergic symptoms chronic rhinosinusitis (CRS) immunity intestinal microbiota microbiological indicator |
| title | Alteration of indicator gut microbiota in patients with chronic sinusitis |
| title_full | Alteration of indicator gut microbiota in patients with chronic sinusitis |
| title_fullStr | Alteration of indicator gut microbiota in patients with chronic sinusitis |
| title_full_unstemmed | Alteration of indicator gut microbiota in patients with chronic sinusitis |
| title_short | Alteration of indicator gut microbiota in patients with chronic sinusitis |
| title_sort | alteration of indicator gut microbiota in patients with chronic sinusitis |
| topic | autoimmunological or allergic symptoms chronic rhinosinusitis (CRS) immunity intestinal microbiota microbiological indicator |
| url | https://doi.org/10.1002/iid3.996 |
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