Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Abstract Neuroinflammation is considered one of the cardinal features of Alzheimer’s disease (AD). Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are surrounded by reactive astrocytes and microglia. Exposure of microglia, the resident myeloid cell of the CNS, to amyl...

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Bibliographic Details
Main Authors: Dawling A. Dionisio-Santos, John A. Olschowka, M. Kerry O’Banion
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Microglia
Cytokines
Innate immunity
Adaptive immunity
Therapeutics
Online Access:http://link.springer.com/article/10.1186/s12974-019-1453-0

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