Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?
Abstract Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical cases series except some traditional options. Though direct replacement of damage...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-03-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-021-02261-5 |
| _version_ | 1818613464277450752 |
|---|---|
| author | Zhuoqun Fang Penghong Chen Shijie Tang Aizhen Chen Chaoyu Zhang Guohao Peng Ming Li Xiaosong Chen |
| author_facet | Zhuoqun Fang Penghong Chen Shijie Tang Aizhen Chen Chaoyu Zhang Guohao Peng Ming Li Xiaosong Chen |
| author_sort | Zhuoqun Fang |
| collection | DOAJ |
| description | Abstract Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical cases series except some traditional options. Though direct replacement of damaged cells may be achieved through differentiation capacity of MSCs, more recent data indicate that various cytokines and chemokines secreted by MSCs are involved in synergetic therapy of RISI by anti-inflammatory, immunomodulation, antioxidant, revascularization, and anti-apoptotic activity. In this paper, we not only discussed different sources of MSCs on the treatment of RISI both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields. |
| first_indexed | 2024-12-16T16:02:32Z |
| format | Article |
| id | doaj.art-df44b9e8e0194efa88f807493143168f |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-16T16:02:32Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-df44b9e8e0194efa88f807493143168f2022-12-21T22:25:26ZengBMCStem Cell Research & Therapy1757-65122021-03-0112111110.1186/s13287-021-02261-5Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?Zhuoqun Fang0Penghong Chen1Shijie Tang2Aizhen Chen3Chaoyu Zhang4Guohao Peng5Ming Li6Xiaosong Chen7Department of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalDepartment of Plastic Surgery, Fujian Medical University Union HospitalAbstract Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical cases series except some traditional options. Though direct replacement of damaged cells may be achieved through differentiation capacity of MSCs, more recent data indicate that various cytokines and chemokines secreted by MSCs are involved in synergetic therapy of RISI by anti-inflammatory, immunomodulation, antioxidant, revascularization, and anti-apoptotic activity. In this paper, we not only discussed different sources of MSCs on the treatment of RISI both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields.https://doi.org/10.1186/s13287-021-02261-5Mesenchymal stem cellsRadiationRadiotherapySkin injuryTreatment |
| spellingShingle | Zhuoqun Fang Penghong Chen Shijie Tang Aizhen Chen Chaoyu Zhang Guohao Peng Ming Li Xiaosong Chen Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? Stem Cell Research & Therapy Mesenchymal stem cells Radiation Radiotherapy Skin injury Treatment |
| title | Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? |
| title_full | Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? |
| title_fullStr | Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? |
| title_full_unstemmed | Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? |
| title_short | Will mesenchymal stem cells be future directions for treating radiation-induced skin injury? |
| title_sort | will mesenchymal stem cells be future directions for treating radiation induced skin injury |
| topic | Mesenchymal stem cells Radiation Radiotherapy Skin injury Treatment |
| url | https://doi.org/10.1186/s13287-021-02261-5 |
| work_keys_str_mv | AT zhuoqunfang willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT penghongchen willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT shijietang willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT aizhenchen willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT chaoyuzhang willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT guohaopeng willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT mingli willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury AT xiaosongchen willmesenchymalstemcellsbefuturedirectionsfortreatingradiationinducedskininjury |