Identification of the O-Glycan Epitope Targeted by the Anti-Human Carcinoma Monoclonal Antibody (mAb) NEO-201

Identification of the O-Glycan Epitope Targeted by the Anti-Human Carcinoma Monoclonal Antibody (mAb) NEO-201

Truncated O-glycans expressed in cancer cells support tumor progression, and they may serve as potential targets to improve the monitoring and treatment of cancers. Previously, we reported that NEO-201 binds to several tumors expressing tumor-associated CEACAM5 and CEACAM6 variants but does not bind...

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Bibliographic Details
Main Authors: Kwong Y. Tsang, Massimo Fantini, Anjum Zaki, Sharon A. Mavroukakis, Maria Pia Morelli, Christina M. Annunziata, Philip M. Arlen
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
O-glycan
monoclonal antibody
antibody-dependent cellular cytotoxicity
NEO-201
cancer immunotherapy
Online Access:https://www.mdpi.com/2072-6694/14/20/4999

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