Human but not mouse hepatocytes respond to interferon-lambda in vivo.

Human but not mouse hepatocytes respond to interferon-lambda in vivo.

The type III interferon (IFN) receptor is preferentially expressed by epithelial cells. It is made of two subunits: IFNLR1, which is specific to IFN-lambda (IFN-λ) and IL10RB, which is shared by other cytokine receptors. Human hepatocytes express IFNLR1 and respond to IFN-λ. In contrast, the IFN-λ r...

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Bibliographic Details
Main Authors: Pascale Hermant, Céline Demarez, Tanel Mahlakõiv, Peter Staeheli, Philip Meuleman, Thomas Michiels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909289?pdf=render

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